Leonidas Seventekidis: From Silent Plaque to Clinical Catastrophe
Leonidas Seventekidis, Doctor of Medicine at Meditzinski Universitet – Plovdiv, shared a post on LinkedIn:
“Atherosclerosis.
A heterogenous degenerative ,progressive disease of the arteries characterized by lipid deposition subintimally.
RFs.
Dyslipidaemia, Systemic hypertension, turbulent flow, Age, Gender at birth, Race, genetic predisposition, lifestyle and metabolic disturbances including diabetes mellitus, hyperhomocysteinemia.
Etiopathogenesis.
Classic theory:
Initiation
LDL cholesterol is deposited in the sub intima which becomes oxidized and ingested by macrophages (foam cells) which persistent accumulation leads to stenosis of arterial lumina with formation of plaque
Conplications
Chronic atherosclerosis tends to form a hypertrophic muscularis, alongside a fibrotic cap ,with tendencies of hemorrhage, thrombosis and arterial wall sclerosis.
When the thrombi detach,there is a risk of embolism and ischemic necroses to the corresponding tissue.
We observe atherosclerosis in most arterial networks:
aorta, iliac arteries, coronaries, carotids.
They produce a clinical picture accordingly:
eg. CAD, Cerebrovascular disease, mesenteric ischemic, claudicattio intermittens etc.
In the picture you can observe the pathology progressing from right to left.
Enjoy.”
Stay updated with Hemostasis Today.
-
May 6, 2026, 02:58Limiaa Babikir: What Is Polyspecific DAT?
-
May 6, 2026, 02:47Karen Rollinson: Grateful to Be Connecting with so Many Families and Advocates at HFA 2026 in New Orleans
-
May 6, 2026, 02:38Moustafa Abdou: Is the Bone Marrow Examination Still the ‘Gold Standard’?
-
May 6, 2026, 02:23Khaled Musallam: When the Worlds of Thalassemia and Hemophilia Converge
-
May 6, 2026, 02:12Caitlin Raymond: How STOP-BABESIOSIS Just Rewrote 40 Years of Practice
-
May 5, 2026, 16:28Nikolay Novitski: A New Era in Cardiovascular Prevention
-
May 5, 2026, 16:23Satyam Arora: Best Abstract Award in Pediatric Apheresis at ASFA 2026 Congress
-
May 5, 2026, 16:17Hannah Omunakwe: Your Sick Child Has a Clot. Did You See That Coming?
-
May 5, 2026, 15:57Venous Thromboembolism Risk in Pregnancy and the Postpartum Period – NBCA