Leonidas Seventekidis: From Silent Plaque to Clinical Catastrophe
Leonidas Seventekidis, Doctor of Medicine at Meditzinski Universitet – Plovdiv, shared a post on LinkedIn:
“Atherosclerosis.
A heterogenous degenerative ,progressive disease of the arteries characterized by lipid deposition subintimally.
RFs.
Dyslipidaemia, Systemic hypertension, turbulent flow, Age, Gender at birth, Race, genetic predisposition, lifestyle and metabolic disturbances including diabetes mellitus, hyperhomocysteinemia.
Etiopathogenesis.
Classic theory:
Initiation
LDL cholesterol is deposited in the sub intima which becomes oxidized and ingested by macrophages (foam cells) which persistent accumulation leads to stenosis of arterial lumina with formation of plaque
Conplications
Chronic atherosclerosis tends to form a hypertrophic muscularis, alongside a fibrotic cap ,with tendencies of hemorrhage, thrombosis and arterial wall sclerosis.
When the thrombi detach,there is a risk of embolism and ischemic necroses to the corresponding tissue.
We observe atherosclerosis in most arterial networks:
aorta, iliac arteries, coronaries, carotids.
They produce a clinical picture accordingly:
eg. CAD, Cerebrovascular disease, mesenteric ischemic, claudicattio intermittens etc.
In the picture you can observe the pathology progressing from right to left.
Enjoy.”
Stay updated with Hemostasis Today.
-
Aug 13, 2026, 18:39Lukas Röthlisberger: Real-World Evidence on Effectiveness and Safety of Rivaroxaban in Children
-
Aug 13, 2026, 18:36Soner Yilmaz: Blood Safety in Türkiye Through More Than 22.5 Million Blood Donations
-
Aug 13, 2026, 18:31Muthukumarasamy Raja: FDA Approval of EZPLAZ Marks a Breakthrough in Emergency Plasma Care
-
Aug 13, 2026, 18:29Peter Zdziarski: Protecting Our Community While Creating a Future Where We Are No Longer Needed
-
Aug 13, 2026, 18:29Morgan E Amos: Thrilled to Receive the Student Research Award From HTRS
-
Aug 13, 2026, 16:38Sheharyar Raza: Plasma Exchange in Multiple Sclerosis
-
Aug 13, 2026, 16:31Juan Manuel Cisneros Carrasco: The True Cost of Blood Donation
-
Aug 13, 2026, 16:25Connie Montgomery: Bridging the Gap Between Patients, Culture and Clinical Trials
-
Aug 13, 2026, 16:16Isabella Presch: A New AI Approach to Protein Engineering