Papa Heme/X
May 13, 2026, 15:19
Papa Heme։ Causes of Isolated Prolonged aPTT Without Bleeding
Papa Heme, Clinical Director and Hematologist at Sarah Cannon Research Institute, shared a post on X:
”Differential diagnoses for an isolated prolonged aPTT with no bleeding
- Lupus anticoagulant
- Factor XII deficiency
- High-molecular-weight kininogen deficiency
- Prekallikrein deficiency
- Heparin contamination
Workup
One-to-one mixing study
If the aPTT corrects, check factor levels such as factor XII deficiency
Lupus anticoagulant typically does not correct on mixing studies․՛՛
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