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Salih Ehsan: Diagnostic Screening Strategy for Hemoglobinopathy Traits
Salih Ehsan/LinkedIn
Aug 5, 2026, 20:15

Salih Ehsan: Diagnostic Screening Strategy for Hemoglobinopathy Traits

Salih Ehsan, Chief Executive Officer at Kulsoom Society of Hematology, shared a post on LinkedIn:

“To pick 6 most common Hemoglobinopathies traits use these steps

  1. Family history of transfusion depends anemia
  2. Ethnicity
  3. CBC ( Erythrocytosis, mild anemia with moderate microcytosis, normal RDW cv with low RDW SD)
  4. Normal iron studies
  5. HPLC finding ( HbA2 and HbE can co-elute , if HbA2 is above 9% suspect HbE, and HbS and HbD can give common peak , solubility test will help to differentiate between HbS and HbD trait)
  6. Peripheral smear, in alpha and beta Thalassemia trait few target cells, while HbE and HbC have mild to moderate target cells. In HbS and HbD trait peripheral smear not helpful.”

Salih Ehsan: Diagnostic Screening Strategy for Hemoglobinopathy Traits

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