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Seema Dawood: Abnormal Nuclear Morphology of Neutrophil 
Seema Dawood/LinkedIn
Jul 4, 2026, 12:45

Seema Dawood: Abnormal Nuclear Morphology of Neutrophil 

Seema Dawood, Medical Laboratory Technologist at The Aga Khan University Hospital, shared a post on LinkedIn:

“Abnormal Nuclear Morphology of Neutrophil

Hyposegmented neutrophils

Neutrophils with nuclei having only 1–2 lobes or appear unsegmented

Unsegmented nucleus:

  1. Round or oval nucleus with no segmentation
  2. Bilobed nucleus: Two-lobed nucleus, often resembling pince-nez glasses

Commonly found in:

  1. Pelger-Huët Anomaly (PHA) – Congenital
  2. Pseudo PelgerHuët Anomaly (PPHA) – Acquired (associated with bone marrow disorders , severe infections , drug-induced or certain types of leukemia)

Hypersegmented neutrophils

Neutrophils with nuclei having more than 5 lobes (especially more than 6).

The nuclear segmentation is excessive but orderly.

Commonly seen in:

  • Megaloblastic Anemia (e.g., Vitamin B12 or Folate deficiency)
  • Myelodysplastic Syndromes
  • Chemotherapy induced bone marrow suppression

Botryoid neutrophils

Neutrophils with multiple nuclear lobes arranged in a radial pattern, often connected by interchromatin bridges.

The nuclei resemble a ‘grape-like cluster’ (botryoid means grape-like).

Commonly observed in:

  • Hyperthermia
  • Heatstroke
  • Severe bacterial infections
  • Extensive burns
  • Severe inflammatory responses
  • Uremia (kidney failure)
  • Chemotherapy or drug toxicity
  • May also be observed in hematologic malignancies such as leukemia or myelodysplastic syndrome (MDS)

The presence of Botryoid Neutrophils is considered a warning sign that ‘the body is experiencing a serious pathological condition or critical systemic stress, particularly involving the immune system, severe infections, toxic states, or hematologic disorders.'”

Seema Dawood: Abnormal Nuclear Morphology of Neutrophil 

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Other posts featuring Seema Dawood on Hemostasis Today.

anemia Blood Botryoid Neutrophils Health Hematology Hemostasis Hemostasis News Hemostasis Today Medicine Myelodysplastic Syndromes Neutrophil Seema Dawood
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