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Spelile Mutupira: Why Hemolysis Remains a Major Laboratory Challenge
Spelile Mutupira/LinkedIn
May 28, 2026, 14:14

Spelile Mutupira: Why Hemolysis Remains a Major Laboratory Challenge

Spelile Mutupira, Medical Laboratory Technologist, shared a post on LinkedIn:

“One of the most common laboratory errors can completely change patient results — hemolysis.

A sample may look acceptable at first glance, but once red blood cells rupture, the integrity of the specimen is compromised.

Hemolysis can falsely increase or alter important laboratory values such as:

  • Potassium
  • LDH
  • AST
  • Magnesium
  • Phosphate

In some cases, it may even lead to unnecessary repeat testing, delayed diagnosis, or incorrect clinical interpretation.

Common causes include:

  • Difficult venipuncture
  • Using a needle that is too small
  • Excessive force during collection
  • Vigorous shaking of tubes
  • Improper specimen transport

This highlights an important truth in laboratory medicine:

Quality begins long before analysis starts.

Pre-analytical errors remain one of the biggest challenges in healthcare diagnostics, and preventing them requires teamwork between phlebotomists, nurses, clinicians, and laboratory professionals.

Behind every accurate result is careful specimen handling.

How does your laboratory reduce hemolysis rates?”

Spelile Mutupira: Why Hemolysis Remains a Major Laboratory Challenge

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