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Wolfgang Miesbach: The Growing Impact of Age-Related Disease in Hemophilia
Wolfgang Miesbach/LinkedIn
Aug 19, 2026, 12:40

Wolfgang Miesbach: The Growing Impact of Age-Related Disease in Hemophilia

Wolfgang Miesbach, Professor of Medicine at Frankfurt University Hospital, shared post on LinkedIn:

“Crucial real-world data on our aging haemophilia population!

As life expectancy improves, our patients face new clinical challenges.

A massive Emory University analysis of US Medicare claims (2000-2020) looking at 2,058 adults (avg age 57.2; 1,735 Hem A or 323 Hem B) reveals critical shifts:

  • Surging Comorbidities: Rates of arthropathy (the highest burden by far), liver disease, CVD, and renal disease are substantially higher in haemophilia patients vs. the matched US population.
  • Elevated Mortality: Males with haemophilia face a 12% higher mortality rate (aHR is equal to 1.12) vs. the general public. (No significant difference in females: aHR is equal to 0.96).
  • The Multiplier Effect: Having common chronic diseases (Cancer, COPD, CHF, CVD, Diabetes) drives a massive 67–300% increase in mortality rates for these patients.

We are managing the first true cohort of aging haemophilia patients. This data screams for a shift toward proactive, multidisciplinary prevention to tackle age-related chronic diseases alongside core bleeding risks.

Kudos to Stacey Fedewa, Christine Kempton, MD, MSc, and the Emory, Hemophilia of Georgia team for this excellent work!”

Wolfgang Miesbach

Other posts featuring Wolfgang Miesbach on Hemostasis Today.

Age-Related Disease Emory University European Association for Haemophilia and Allied Disorders haemophilia A Haemophilia B Health Hematology Hemophilia Hemophilia of Georgia Hemostasis Hemostasis News Hemostasis Today Medicine
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