Alan Nurden: Looking Beyond Bleeding in VWD
Alan Nurden, Emeritus Research Director at CNRS, Co-Founder of the French National Reference Centre for Inherited Platelet Disorders (CRPP), shared on LinkedIn about a recent article by Dawn Swan et al, published in RPTH Journal:
”A well thought-out and much-needed assessment of the effects of VWD extending beyond the classical bleeding symptoms.
Could someone now do this for the platelet-based bleeding disorder, Glanzmann thrombasthenia (GT)?
And for GT it would be interesting to go beyond well-studied European and North American populations to include Arab, Pakistani, Indian, Chinese, African and South-American populations where cultural and religious heritage may have a bearing on lifestyle.
A complication of GT is that two genes are involved (ITGA2B and ITGB3) and despite hints from older studies the question of whether ITGB3 defects that lead to both alphaIIbbeta3 and alphavbeta3 deficiencies can influence such parameters as bone density and fertility remain unresolved.”
Title: Von Willebrand disease: more than just a bleeding disorder
Authors: Dawn Swan, Michelle Sholzberg, Bethany Samuelson Bannow, Jecko Thachil
Read the Full Article on RPTH Journal
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