From Qvevri to Capillaries: Archil Jaliashvili on the Bioactive Chemistry of Georgian Wine
Archil Jaliashvili, Co-owner, General Manager of SkinAI, Co-Chief Executive Officer at GeoBio Pharm, reposted BHOC โ Biological Hemoglobin Oxygen Carrierโs post onย LinkedIn:
“๐๐ฒ๐ผ๐ฟ๐ด๐ถ๐ฎ ๐ฃ๐ผ๐๐ #3
From qvevri to capillaries: when Georgian wine meets oxygenation and red blood cells
- ๐๐ฒ๐ผ๐ฟ๐ด๐ถ๐ฎ ๐ถ๐ ๐๐ต๐ฒ ๐บ๐ผ๐๐ต๐ฒ๐ฟ๐น๐ฎ๐ป๐ฑ ๐ผ๐ณ ๐๐ถ๐ป๐ฒ, with archaeological evidence of winemaking dating back ๐ผ๐๐ฒ๐ฟ ๐ด,๐ฌ๐ฌ๐ฌ ๐๐ฒ๐ฎ๐ฟ๐, continuously practiced to this day.
- Neolithic grape residues and tartaric acid traces found in ancient clay vessels (Qvevri) confirm wine fermentation as early as ๐ฒ๐ฌ๐ฌ๐ฌโ๐ฑ๐ด๐ฌ๐ฌ ๐๐.
- This method is so distinctive that ๐จ๐ก๐๐ฆ๐๐ข recognizes Georgian Qvevri winemaking as ๐๐ป๐๐ฎ๐ป๐ด๐ถ๐ฏ๐น๐ฒ ๐๐๐น๐๐๐ฟ๐ฎ๐น ๐๐ฒ๐ฟ๐ถ๐๐ฎ๐ด๐ฒ ๐ผ๐ณ ๐๐๐บ๐ฎ๐ป๐ถ๐๐.
- Add to this Georgiaโs extraordinary diversity of ๐ฑ๐ฌ๐ฌ+ ๐ถ๐ป๐ฑ๐ถ๐ด๐ฒ๐ป๐ผ๐๐ ๐ด๐ฟ๐ฎ๐ฝ๐ฒ ๐๐ฎ๐ฟ๐ถ๐ฒ๐๐ถ๐ฒ๐.
Beyond culture and archaeology, ๐๐ฒ๐ผ๐ฟ๐ด๐ถ๐ฎ๐ป ๐ฟ๐ฒ๐ฑ ๐๐ถ๐ป๐ฒ ๐ผ๐ณ๐ณ๐ฒ๐ฟ๐ ๐ฎ ๐ฐ๐ผ๐บ๐ฝ๐ฒ๐น๐น๐ถ๐ป๐ด ๐ฝ๐ต๐๐๐ถ๐ผ๐น๐ผ๐ด๐ถ๐ฐ๐ฎ๐น ๐ฝ๐ฒ๐ฟ๐๐ฝ๐ฒ๐ฐ๐๐ถ๐๐ฒ.
The biological effects linked to red wine are driven largely not by ethanol, but by ๐ฝ๐ผ๐น๐๐ฝ๐ต๐ฒ๐ป๐ผ๐น๐โincluding ๐ฟ๐ฒ๐๐๐ฒ๐ฟ๐ฎ๐๐ฟ๐ผ๐น, anthocyanins, catechins, proanthocyanidins and likely many yet unidentified compounds.
๐ฅ๐ฒ๐๐ฒ๐ฎ๐ฟ๐ฐ๐ต ๐๐ต๐ผ๐๐ ๐๐ต๐ฒ๐๐ฒ ๐ฐ๐ผ๐บ๐ฝ๐ผ๐๐ป๐ฑ๐ ๐ฐ๐ฎ๐ป:
- ๐ฃ๐ฟ๐ผ๐๐ฒ๐ฐ๐ ๐ฒ๐ฟ๐๐๐ต๐ฟ๐ผ๐ฐ๐๐๐ฒ ๐บ๐ฒ๐บ๐ฏ๐ฟ๐ฎ๐ป๐ฒ๐, reducing lipid peroxidation and preserving red blood cell deformabilityโkey for efficient capillary oxygen unloading.
- ๐ฆ๐๐ฝ๐ฝ๐ผ๐ฟ๐ ๐ถ๐ป๐๐ฟ๐ฎ๐ฐ๐ฒ๐น๐น๐๐น๐ฎ๐ฟ ๐ฎ๐ป๐๐ถ๐ผ๐ ๐ถ๐ฑ๐ฎ๐ป๐ ๐๐๐๐๐ฒ๐บ๐ in RBCs (including glutathione), helping maintain haemoglobin in a functional redox state.
- ๐๐บ๐ฝ๐ฟ๐ผ๐๐ฒ ๐ฒ๐ป๐ฑ๐ผ๐๐ต๐ฒ๐น๐ถ๐ฎ๐น ๐ฎ๐ป๐ฑ ๐บ๐ถ๐ฐ๐ฟ๐ผ๐๐ฎ๐๐ฐ๐๐น๐ฎ๐ฟ ๐ณ๐๐ป๐ฐ๐๐ถ๐ผ๐ป, enhancing nitric-oxideโmediated vasodilation, tissue perfusion, and oxygen delivery.
- ๐ ๐ผ๐ฑ๐๐น๐ฎ๐๐ฒ ๐๐ต๐ฒ ๐ด๐๐ ๐บ๐ถ๐ฐ๐ฟ๐ผ๐ฏ๐ถ๐ผ๐บ๐ฒ, increasing microbial diversity and beneficial taxa (e.g., ๐๐ช๐ง๐ช๐ฅ๐ฐ๐ฃ๐ข๐ค๐ต๐ฆ๐ณ๐ช๐ถ๐ฎ, ๐๐ข๐ค๐ต๐ฐ๐ฃ๐ข๐ค๐ช๐ญ๐ญ๐ถ๐ด, ๐๐ณ๐ฆ๐ท๐ฐ๐ต๐ฆ๐ญ๐ญ๐ข), alongside higher butyrate-producing species.
- ๐ฅ๐ฒ๐ฑ๐๐ฐ๐ฒ ๐น๐ผ๐-๐ด๐ฟ๐ฎ๐ฑ๐ฒ ๐๐๐๐๐ฒ๐บ๐ถ๐ฐ ๐ถ๐ป๐ณ๐น๐ฎ๐บ๐บ๐ฎ๐๐ถ๐ผ๐ป, with reported decreases in markers such as hs-CRP and improvements in endothelial biomarkers after moderate or dealcoholised red wine intake.
๐๐ป ๐๐ต๐ผ๐ฟ๐: wine influences ๐บ๐ฒ๐๐ฎ๐ฏ๐ผ๐น๐ถ๐๐บ ๐ฎ๐ป๐ฑ ๐ผ๐ ๐๐ด๐ฒ๐ป ๐ฑ๐ฒ๐น๐ถ๐๐ฒ๐ฟ๐ ๐ฒ๐ณ๐ณ๐ถ๐ฐ๐ถ๐ฒ๐ป๐ฐ๐ .
- The Caucasus also served as a ๐ด๐ฒ๐ป๐ฒ๐๐ถ๐ฐ ๐ฟ๐ฒ๐ณ๐๐ด๐ฒ ๐ณ๐ผ๐ฟ ๐ด๐ฟ๐ฎ๐ฝ๐ฒ๐๐ถ๐ป๐ฒ๐, preserving ancient varieties through events like the 19th-century phylloxera crisis that reshaped European viticulture.
๐๐ฒ๐ผ๐ฟ๐ด๐ถ๐ฎ๐ป ๐๐ถ๐ป๐ฒ is not just history it is ๐๐ป๐ถ๐พ๐๐ฒ ๐ณ๐ฒ๐ฟ๐บ๐ฒ๐ป๐๐ฎ๐๐ถ๐ผ๐ป ๐๐ฒ๐ฐ๐ต๐ป๐ผ๐น๐ผ๐ด๐ ๐ฎ๐ป๐ฑ ๐ฏ๐ถ๐ผ๐ฎ๐ฐ๐๐ถ๐๐ฒ ๐ฐ๐ต๐ฒ๐บ๐ถ๐๐๐ฟ๐, intersecting with modern concepts of ๐บ๐ถ๐ฐ๐ฟ๐ผ๐ฐ๐ถ๐ฟ๐ฐ๐๐น๐ฎ๐๐ถ๐ผ๐ป, ๐บ๐ถ๐ฐ๐ฟ๐ผ๐ฏ๐ถ๐ผ๐บ๐ฒ ๐๐๐ฝ๐ฝ๐ผ๐ฟ๐, ๐ฎ๐ป๐ฑ ๐ผ๐ ๐๐ด๐ฒ๐ป๐ฎ๐๐ถ๐ผ๐ป-๐ณ๐ผ๐ฐ๐๐๐ฒ๐ฑ ๐๐ต๐ฒ๐ฟ๐ฎ๐ฝ๐ฒ๐๐๐ถ๐ฐ๐.”
Discover the latest in Hemostasis Today.
-
Jan 8, 2026, 05:51Dominika Jฤdrzejewska Akbaล Links Sleep Deprivation, Obesity, and Stroke
-
Jan 8, 2026, 05:42Rob Maloney: A Bruise that Did Not Go Away…
-
Jan 8, 2026, 05:33Matรญas J Alet on Treating Early Neurological Deterioration in Lacunar Strokeย
-
Jan 8, 2026, 05:11Thomas Meinel Shares The English Stroke Guidelines 2026
-
Jan 8, 2026, 05:03Hilla Ben-Pazi: We Were Pleased to Receive a Grant from the Israeli Ministry of Economy
-
Jan 8, 2026, 04:24Nikhil Agrawal Breaks Down Perioperative Anticoagulation
-
Jan 8, 2026, 03:58Louise St Germain Bannon Appointed Interim Executive Director of ISTH
-
Jan 8, 2026, 03:47Wolfgang Miesbach on Fernando Corrales-Medina’s Team’s Latest Cross-Sectional Study on Haemophilia
-
Jan 8, 2026, 03:28Rick Matthews: Powerful Perspective from Erin and the NBCA Team