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Updated from ASH and ACCP – DOAC Dosing for VTE: What You Need to Know
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Jun 3, 2025, 14:50

Updated from ASH and ACCP – DOAC Dosing for VTE: What You Need to Know

Dr. Chokri Ben Lamine shared on X:

Based on ASH 2024 and ACCP 2021 Guidelines

”VTE Treatment (Therapeutic Anticoagulation)”

-Apixaban:
▸ 10 mg BID × 7 days → 5 mg BID
▸ Optional: 2.5 mg BID after 6 months (extended use)

Rivaroxaban:
▸ 15 mg BID × 21 days → 20 mg OD
▸ Optional: 10 mg OD after 6 months

Edoxaban:
▸ Parenteral anticoagulation × 5–10 days → 60 mg OD
▸ Reduce to 30 mg if CrCl 15–50 or weight ≤60 kg

Dabigatran:
▸ Parenteral anticoagulation × 5–10 days → 150 mg BID

VTE Prophylaxis (Post-op, High Risk)
-Apixaban: 2.5 mg BID

-Rivaroxaban: 10 mg OD

-Dabigatran: 110 mg Day 1 → 220 mg OD

-Edoxaban: Not typically used for primary prophylaxis

 Key Precautions
-Age >75

-CrCl <30 mL/min

-Low body weight

-Active cancer → Consider LMWH

Always assess bleeding & renal function risk.”

Updated from ASH and ACCP - DOAC Dosing for VTE: What You Need to Know

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