The Body Explained/X
Sep 6, 2025, 13:48
The Body Explained on Blood Clotting Pathways
The Body Explained shared an insightful post on X:
“Blood clotting is life’s emergency repair system
When a vessel is injured, exposed endothelium and collagen trigger platelets and clotting factors.
The cascade has 2 arms: intrinsic (contact activation) and extrinsic (tissue factor). Both converge at the common pathway to form fibrin.
- Intrinsic pathway: Factors XII → XI → IX → VIII. This is activated by collagen and negatively charged surfaces inside vessel.
- Extrinsic pathway: Factor VII + tissue factor (III) released from damaged endothelial cells.
Both activate Factor X, launching the common pathway.
- Factor X + V → Prothrombin (II) → Thrombin
- Thrombin converts Fibrinogen (I) → Fibrin mesh
- Cross-linked by Factor XIII for clot stability.
Balance is vital:
Too little = bleeding (e.g., hemophilia, factor deficiencies)
Too much = thrombosis (MI, stroke, DVT)”
Stay informed with Hemostasis Today.
-
Aug 8, 2026, 17:02Mohammed Murad Hossain: Highlights from the 2nd Haematology and HSCT Workshop in Dhaka
-
Aug 8, 2026, 16:57Mohammed Al Kanan: Advancing Therapeutic Drug Monitoring in Pediatric Aplastic Anemia
-
Aug 8, 2026, 16:38Dmytro Samofalov: FDA-Approved Freeze-Dried Plasma in Modern Warfare
-
Aug 8, 2026, 16:33Roshan Koshy Jacob: When Unexplained Severe Anemia Points to Myelodysplastic Neoplasms
-
Aug 8, 2026, 16:21Sheharyar Raza: Transfusion Medicine in the Age of AI Slop
-
Aug 8, 2026, 16:16David McIntosh: A Medico-Scientific Challenge
-
Aug 8, 2026, 16:05Anirban Sen Gupta: Celebrating Science, Innovation, and Connection at Hemostasis GRC
-
Aug 8, 2026, 15:54Satya Prakash Yadav։ How Prophylaxis Changes Life for People With Hemophilia
-
Aug 8, 2026, 15:51Eugene Fan: Dual-Model Explainability in Blood Cell Classification