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Dec 28, 2025, 15:31

Francisco Epelde: Development and Validation of a Nomogram for Predicting Bleeding Risk in Patients with PE

Francisco Epelde, Attending Physician, internal Medicine Service at Parc Taulí University Hospital, posted on LinkedIn:

” ‘Development and Validation of a Nomogram for Predicting Bleeding Risk in Patients with Pulmonary Embolism’
DOI: 10.3389/fmed.2025.1692156

Authors: Tian Ye, Wanlin Lei, Maofeng Wang, Lili Xu

Read full article here or print here.

As Academic Editor, I had the privilege of overseeing this excellent study by Ye et al. (Wenzhou Medical University, China), which provides an important step toward personalized medicine in pulmonary embolism (PE) management.

Why this work matters:
Bleeding remains one of the most serious complications of anticoagulation therapy in PE. Current clinical scores—such as HAS-BLED or ATRIA—were not specifically developed for this population and often fail to capture the true hemorrhagic risk in acute PE settings.

This study overcomes that gap by developing and validating the first PE-specific bleeding risk nomogram, integrating six easily measurable clinical parameters: prior bleeding history, renal insufficiency, red blood cell count, systolic pressure, cerebral infarction, and creatinine.

Using data from 5,632 hospitalized patients, the model showed strong predictive performance (AUC 0.73–0.76) and was internally validated with excellent calibration. Importantly, decision curve analysis demonstrated clear clinical benefit—reducing major bleeding by up to 42% compared to standard care.

In essence, this paper exemplifies how data-driven tools can translate complex statistical modeling into bedside decision-making, supporting safer, more individualized anticoagulation strategies for patients with pulmonary embolism.”

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ATRIA Francisco Epelde HAS-BLED Health Hemostasis Hemostasis Today Lili Xu Maofeng Wang Medicine pulmonary embolism (PE) thrombosis Tian Ye Wanlin Lei Wenzhou Medical University

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