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Caitlin Raymond: Plasma Chasers and the Quiet Rituals of Apheresis
Caitlin R./LinkedIn
Nov 14, 2025, 03:14

Caitlin Raymond: Plasma Chasers and the Quiet Rituals of Apheresis

Caitlin Raymond, Assistant Professor of Pathology and Transfusion Medicine at the University of Wisconsin-Madison, shared on LinkedIn:

”I wrote a new piece this week about something I hadn’t encountered until I became an attending: the “plasma chaser.”

It’s not in ASFA guidelines, not in textbooks, and not something I ever saw in residency or fellowship. But it came up twice in two days, and it made me pause and think about how we make replacement-fluid decisions after recent procedures — and how much of that work happens in the gray space where physiology, experience, and uncertainty meet.

What I found, digging into the peer-reviewed survey data, is striking:
– 8.9% of clinicians still use albumin-only replacement one day after major surgery, a number much higher than I was expecting.
– Clinicians are split about 50/50 on using albumin vs plasma for replacement fluid a day following a minor procedure.
– For a patient scenario with no bleeding risk, 5.3% of clinicians will still use plasma, also higher than I was expecting.

There’s a story in those numbers – about risk perception, about judgment, and about how small, experience-driven practices evolve when formal guidance is limited.

In my blog post, I tried to unpack this… not to prescribe a standard, but to explore how we think through these nuanced decisions and why certain rituals persist in medicine. And also where a rational, physiologic framework can help us cut through the uncertainty.

If you’re interested in the intersection of transfusion medicine, clinical reasoning, and the quiet rituals we inherit in practice, you can read the full piece here.

Would love to hear how others approach post-procedure TPE decisions in their practice – especially where your institution aligns with (or diverges from) the survey data.”

Plasma

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Albumin apheresis Caitlin Raymond Health Hematology Hemostasis Hemostasis Today Medicine 𝗣𝗹𝗮𝘀𝗺𝗮 plasma chaser thrombosis Transfusion Medicine University of Wisconsin-Madison
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