Tareq Abadl: Mesothelial Cells in Body Fluids
Tareq Abadl, Medical Laboratory Specialist and Director of the Blood Bank at Dr. Abdelkader Al-Mutawakkil Hospital, posted on LinkedIn:
”Mesothelial Cells in Body Fluids
A key finding in serous fluid cytology
What Are Mesothelial Cells?
Mesothelial cells come from a thin membrane (mesothelium) that lines major body cavities and surrounds internal organs.
Commonly found in serous fluids:
- Pleural fluid – lining the lungs
- Peritoneal fluid – lining the abdominal cavity
- Pericardial fluid – lining the heart
Characteristics of Mesothelial Cells
These cells have distinct morphological features that help differentiate them from macrophages or malignant cells.
- Size and Arrangement
– Large cells
– May appear singly, in clusters, or in tight clumps
- Nucleus
– Large, round, centrally located nucleus
– Smooth nuclear borders
– 1–2 prominent nucleoli, usually deeply staining
- Cytoplasm
– Basophilic (blue-purple staining)
– Often shows frayed, ruffled, or “fuzzy” edges
– May contain small pinpoint vacuoles
– Do NOT contain large foamy vacuoles like macrophages/histiocytes
Extra Notes (High-Yield)
• Reactive mesothelial cells may become larger and show binucleation during inflammation
• They maintain a uniform nuclear-to-cytoplasmic ratio, unlike many malignant cells
• Presence alone does not indicate disease – they are normal components of serous fluids.”
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