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Zain Khalpey: Did You Know 1 in 6 Ischemic Strokes Has no Clearly Identified Cause?
Zain Khalpey, MD, PhD, FACS/LinkedIn
Oct 30, 2025, 07:15

Zain Khalpey: Did You Know 1 in 6 Ischemic Strokes Has no Clearly Identified Cause?

Zain Khalpey, Chief Medical AI Officer, Chair of Applied Clinical AI, Director, Khalpey AI Lab at ATARI AI, shared a post on LinkedIn:

“Did you know 1 in 6 ischemic strokes has no clearly identified cause?

These are known as Embolic Strokes of Undetermined Source (ESUS) and they represent one of the greatest challenges in stroke prevention and care.

A new European Heart Journal consensus statement offers a comprehensive, multidisciplinary framework to better understand and manage ESUS, integrating cardiology, neurology, and vascular insights.

This pivotal paper reframes how we assess risk not by guessing a single cause, but by evaluating the total thromboembolic burden across all potential sources:

  • Atrial and ventricular disease
  • Patent foramen ovale (PFO)
  • Atherosclerosis
  • Valvular disorders
  • Cancer-associated coagulopathies

Title: Embolic strokes of undetermined source: a clinical consensus statement of the ESC Council on Stroke, the European Association of Cardiovascular Imaging and the European Heart Rhythm Association of the ESC

Authors: George Ntaios, Helmut Baumgartner, Wolfram Doehner, Erwan Donal, Thor Edvardsen, Jeff S Healey, Bernard Iung, Hooman Kamel, Scott E Kasner, Eleni Korompoki, Babak B Navi, Christian Pristipino, Luca Saba, Renate B Schnabel, Emma Svennberg, Gregory Y H Lip

Zain Khalpey: Did You Know 1 in 6 Ischemic Strokes Has no Clearly Identified Cause?

Read the full open-access consensus here:

Follow Zain Khalpey for more on Ai & Healthcare.”

Stay updated with Hemostasis Today.

Babak B Navi Bernard Iung Christian Pristipino Eleni Korompoki Embolic Strokes of Undetermined Source (ESUS) Emma Svennberg Erwan Donal European Heart Journal George Ntaios Gregory Y.H. Lip Health Helmut Baumgartner Hematology Hemostasis Hemostasis Today Hooman Kamel Ischemic Strokes Jeff S Healey Luca Saba Medicine Renate B Schnabel Scott E. Kasner Thor Edvardsen Wolfram Doehner Zain Khalpey
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