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Zain Khalpey: Did You Know 1 in 6 Ischemic Strokes Has no Clearly Identified Cause?
Oct 30, 2025, 07:15

Zain Khalpey: Did You Know 1 in 6 Ischemic Strokes Has no Clearly Identified Cause?

Zain Khalpey, Chief Medical AI Officer, Chair of Applied Clinical AI, Director, Khalpey AI Lab at ATARI AI, shared a post on LinkedIn:

“Did you know 1 in 6 ischemic strokes has no clearly identified cause?

These are known as Embolic Strokes of Undetermined Source (ESUS) and they represent one of the greatest challenges in stroke prevention and care.

A new European Heart Journal consensus statement offers a comprehensive, multidisciplinary framework to better understand and manage ESUS, integrating cardiology, neurology, and vascular insights.

This pivotal paper reframes how we assess risk not by guessing a single cause, but by evaluating the total thromboembolic burden across all potential sources:

  • Atrial and ventricular disease
  • Patent foramen ovale (PFO)
  • Atherosclerosis
  • Valvular disorders
  • Cancer-associated coagulopathies

Title: Embolic strokes of undetermined source: a clinical consensus statement of the ESC Council on Stroke, the European Association of Cardiovascular Imaging and the European Heart Rhythm Association of the ESC

Authors: George Ntaios, Helmut Baumgartner, Wolfram Doehner, Erwan Donal, Thor Edvardsen, Jeff S Healey, Bernard Iung, Hooman Kamel, Scott E Kasner, Eleni Korompoki, Babak B Navi, Christian Pristipino, Luca Saba, Renate B Schnabel, Emma Svennberg, Gregory Y H Lip

Zain Khalpey: Did You Know 1 in 6 Ischemic Strokes Has no Clearly Identified Cause?

Read the full open-access consensus here:

Follow Zain Khalpey for more on Ai & Healthcare.”

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