Abdulrahman Nasiri: Understanding and Managing Chronic Pain in Transfusion-Dependent Thalassemia
Abdulrahman Nasiri, The Evolving Role of Romiplostim in SAA, shared a post on LinkedIn about a recent article he and his colleagues co-authored, published in Hemoglobin, adding:
“I am pleased to share our newly published review in Hemoglobin:
The Silent Epidemic: A Scoping Review of Chronic Pain Etiology and Management Strategies in Transfusion-Dependent Thalassemia
Advances in transfusion support and iron chelation have transformed transfusion-dependent thalassemia into a chronic condition. Yet this progress has also revealed an important and often overlooked burden: chronic pain.
Our review found that chronic pain affects approximately 32% to 55% of adults with transfusion-dependent thalassemia, while more than 90% of affected patients report moderate to severe pain.
The causes are multifactorial and include osteoporosis, chelation-related arthropathy, extramedullary hematopoiesis, endocrine dysfunction, fractures, and treatment-related adverse effects.
Despite its clinical impact, pain assessment and management remain inconsistent. We therefore propose a structured, disease-informed approach that integrates validated pain assessment, correction of metabolic and endocrine abnormalities, physical therapy, antiresorptive treatment when indicated, careful selection of analgesics, and optimization of transfusion and iron chelation therapy.
Improving survival is no longer enough. The progress achieved in life expectancy must be matched by meaningful improvements in comfort, daily function, and quality of life.
I am grateful to my coauthors for their valuable contributions and collaboration.”
Title: The Silent Epidemic: A Scoping Review of Chronic Pain Etiology and Management Strategies in Transfusion-Dependent Thalassemia
Authors: Abdulrahman Nasiri ,Mostafa F. Mohammed Saleh ,Manal Alshammari ,Ali Alahmari ,Reem Alkharras ,Fahad Almohareb, Hazza Alzahrani
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