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1 Hypothesis, Multiple Implications: Adenoviral Vector Vaccines and Thrombosis with Thrombocytopenia Syndrome
RPTH Journal / LinkedIn
Jul 26, 2025, 17:27

1 Hypothesis, Multiple Implications: Adenoviral Vector Vaccines and Thrombosis with Thrombocytopenia Syndrome

The RPTH Journal (Research and Practice in Thrombosis and Haemostasis) shared an insightful post on LinkedIn:

”This new study investigates adenoviral vector vaccine-associated thrombosis/thrombocytopenia risk.

  • Adenoviral vectors can infect megakaryocytes
  • Concurrent infection may increase chemokine receptor expression

Senior Author: Joseph Torresi”

Read the full article here.

In the article ”Adenovirus vectors can infect mouse megakaryocytes – implications for vaccine-induced thrombosis/thrombocytopenia” by Simon Collett, Joseph Torresi et al. in the RPTH Journal, a potential role of adenoviral vector vaccines in inducing TTS is discussed.

Adenoviruses, adenoviral vector-based vaccines, and gene delivery systems have been associated with thrombosis with thrombocytopenia syndrome (TTS), a rare but serious complication.

The precise mechanisms underlying this condition remain unclear.

It was previously hypothesized that megakaryocytes (MKs)—the precursor cells responsible for platelet production—play a central role in the development of adenovirus- or vector-induced TTS.

Emerging evidence supports the notion that MKs are a heterogeneous population, including subsets with distinct immune-related functions.

This study demonstrates that adenoviral infection preferentially targets higher-ploidy CD41⁺CD42⁺ MKs and those expressing high levels of CXCR4 (CXCR4^hi).

These findings implicate specific MK subsets and surface receptors in the cellular response to adenoviral exposure and provide a potential mechanistic link to thrombocytopenia and thrombotic events observed post-vaccination or gene therapy.

1 Hypothesis, Multiple Implications: Adenoviral Vector Vaccines and Thrombosis with Thrombocytopenia Syndrome

Find all the latest scientific advancements in the World of Thrombosis posted in Hemostasis Today.

Adenoviral Vector Vaccines gene delivery systems Health Hematology Hemostasis Today Joseph Torresi Medicine megakaryocytes MKs rpth Simon Collett thrombosis with thrombocytopenia syndrome TTS
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