Alan Nurden: Angiodysplasia and Gastrointestinal Bleeding in Von Willebrand Disease
Alan Nurden, Emeritus Research Director at CNRS, Co-Founder of the French National Reference Centre for Inherited Platelet Disorders (CRPP), shared on LinkedIn about a recent article by Adela Constantinescu-Bercu et al, published in Blood:
“This online paper attacks an important problem, angiodysplasia and gastrointestinal (GI) bleeding in von Willebrand disease. The authors show a role for VWF in the secretion of angiopoietin-2 (angpt-2) from endothelial cells and alterations in the angpt-1/2 ratio at lesion sites in VWD-/- mice. Significantly, inhibition of angpt-2 normalized vascular remodeling in the mice.
From a personal point of view, I would like to see a similar study in the inherited platelet disorder, Glanzmann thrombasthenia (GT), where GI bleeding is also a terrible problem for a subset of patients. Platelets secrete angpt-1 and its role is considered anti-inflammatory.
It would be interesting to measure the angpt-1/2 ratio in GT patients with nor without angiodysplasia and to compare those whose gene defects affect ITGA2B (and are restricted to alphaIIbbeta3 in platelets), to those whose gene defects affect ITGB3 and extend to alphavbeta3, a purported target of angpt-2 in endothelial cells.”
Title: Von Willebrand Factor Deficiency Impairs Angiogenesis via Angiopoietin-2: Relevance for Gut Angiodysplasia
Authors: Adela Constantinescu-Bercu, Koval E Smith, Shuo Yi Wong, Mattia Ballerini, Alessia Nastro, Benjamin G Wiggins, Daniela Pirri, Yucheng Li, Juun Anora Maria Evers, Olga Tsiamita, Matthew Dibble, Charis Pericleous, Koralia E Paschalaki, Graeme M Birdsey, Jeremiah Bernier-Latmani, Tatiana V Petrova, Mike A Laffan, Suthesh Sivapalaratnam, Marco Rasponi, Anna M. Randi
Read the Full Article on Blood.
Stay updated on all scientific advances with Hemostasis Today.
-
Apr 3, 2026, 17:59A Free Hemoglobin Screening Camp for Kaikadi Vasti and Eramushti Community Women – Hope Foundation Sironcha
-
Apr 3, 2026, 17:53Carlos Henrique Del Carlo: HFpEF and Iron Deficiency – Why Treating the Mitochondrial Engine Matters More Than We Thought?
-
Apr 3, 2026, 17:46Michelle Leona Cecil: A Call to Protect Patient Care and The Nation’s Blood Supply for Blood Disorders Community
-
Apr 3, 2026, 17:38Shahab Sheikhalishahi: A Rare Case of Portal Vein Thrombosis After Echis Carinatus Envenomation
-
Apr 3, 2026, 17:33Kimberly Ha: Epia Neuro Aims to Restore Movement in Stroke Survivors
-
Apr 3, 2026, 17:28Ryan Perry: Heart and Stroke Announces 2026 Grants-in-Aid Indigenous Research Stream Funding Opportunity
-
Apr 3, 2026, 17:21Maxime Dely: A Meaningful Journey of 14 years in Blood Transfusion
-
Apr 3, 2026, 17:19Arun V J: Don’t Miss TRANSCON 2026 – A Direct Pathway Into India’s Clinical and Institutional Network
-
Apr 3, 2026, 17:17Louise St. Germain Bannon: Preparating for ISTH 2026 and Highlighting Best Aspects of Congress