Anirban Sen Gupta: Lyophilized Synthetic Platelets as a Stable Powder for Rapid Hemorrhage Control
Anirban Sen Gupta, Wallace R. Persons Professor of Engineering in the Department of Biomedical Engineering at Case Western Reserve University, shared a post on LinkedIn about recent article by Ujjal Didar Singh Sekhon et al., published in Advanced Science, adding:
“Almost 8 years ago, at an MHSRS meeting, as I was presenting on our early phase research on SynthoPlate solution, I had a very intriguing conversation with multiple stakeholders who asked:
Can you make it into a powder and will it still work if you reconstitute that in water?
At long last, I can proudly say:
Yes we can!
Thrilled to report the first-in-world demonstration of Lyophilized Synthetic Platelet powder that:
- Can be manufactured at scale
- Is shelf stable at RT and 4C for at least a year
- Shelf stable at 50C for at least 2 months
- Highly portable (low carry weight as powder)
- Can be aqueous reconstituted in 1 min
- Preserves peptide bioactivity over long storage period
- Works in prophylactic and emergency settings
This can enable hemorrhage control capabilities at the point-of-injury (e.g. outside of hospitals in civilian and military settings) where platelets are unavailable!!
Congratulations to Ujjal Didar Singh Sekhon, from Haima Therapeutics, and Dante Disharoon from our team at Case Western Reserve University Department of Biomedical Engineering, for co-leading these studies!
Thank you to all at Haima and CWRUBME that teamed up for this.
And thank you Matthew D. Neal, Phil Spinella and Susan Shea for your collaborations!
Grateful to Defense Health Agency Research and Development-Medical Research and Development Command for supporting this R&D.”
Title: Lyophilized Synthetic Platelets: In Vitro Characterization and in Vivo Evaluation in Mouse Thrombocytopenia Model
Authors: Ujjal Didar Singh Sekhon, Dante Disharoon, Shrijal S. Desai, Baylee Traylor, Emily Gahagan, Emma Quill, Kristin Aldridge, Norman F. Luc, Sonali Rohiwal, Shruti Raghunathan, Rebecca Ahn, Sana Syed, Alexander Dornback, Bipin Chakravarthy Paruchuri, Andrew Ditto, Susan M. Shea, Philip C. Spinella, Matthew D. Neal, Michael A. Bruckman, Christa L. Pawlowski, Anirban Sen Gupta
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