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Assefa Desalew: RhD-Negative Status and Adverse Perinatal Outcomes in Eastern Ethiopia
Assefa Desalew/LinkedIn
Apr 20, 2026, 17:12

Assefa Desalew: RhD-Negative Status and Adverse Perinatal Outcomes in Eastern Ethiopia

Assefa Desalew, PHD Fellow at Leiden University Medical Center, shared on LinkedIn about a recent article he and his colleagues co-authored, published in AJOG Global Reports, adding:

“As part of the baseline findings from the AFRICARhE–Ethiopia project and my PhD work, we assessed adverse perinatal outcomes associated with RhD status in a multicenter cohort (~7,000 births).

Key findings:

  • RhD-negative women had 2-fold higher odds of adverse perinatal outcomes
  • Clinical signs highly suggestive of HDFN were observed in 5.8% of RhD-negative vs 0.2% of RhD-positive women (P<.0001)

These findings indicate a substantial and preventable burden of RhD-mediated HDFN, reflecting persistent inequities in access to standard preventive care.

Strengthening anti-RhD immunoprophylaxis and antenatal antibody screening remains critical.

I am deeply grateful to my promotors (Ellen van der Schoot, Thomas van den Akker) and co-promotors (Joanne Verweij, Abera Kenay Tura, Tadesse Gure) for their mentorship and guidance throughout this work.”

Title: Adverse perinatal outcomes indicative of RhD-mediated hemolytic disease of the fetus and newborn in Eastern Ethiopia: evidence of maternal health inequity in a multicenter cohort study

Authors: Assefa Desalew, C. Ellen van der Schoot, Rafiki N. Mjema, Thomas van den Akker, Tienke Vermeiden, Henk Schonewille, Jeremia J. Pyuza, Tadesse Gure , E.J.T. (Joanne) Verweij, Abera Kenay Tura

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Abera Kenay Tura AJOG Global Reports Assefa Desalew C. Ellen van der Schoot E.J.T. (Joanne) Verweij Health Hematology Hemostasis Hemostasis News Hemostasis Today Henk Schonewille Jeremia J. Pyuza Medicine Rafiki N. Mjema Tadesse Gure Thomas van den Akker Tienke Vermeiden
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