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Caroline Dixon and Colleagues on LMWH Dosing to Reduce The Risk of VTE in Pregnant Women With Inherited ATD
Caroline Dixon/LinkedIn
Oct 12, 2025, 01:26

Caroline Dixon and Colleagues on LMWH Dosing to Reduce The Risk of VTE in Pregnant Women With Inherited ATD

Journal of Thrombosis and Haemostasis (JTH) shared on LinkedIn:

”Anti-Xa–directed low-molecular-weight heparin dosing to reduce venous thromboembolism in pregnant women with inherited antithrombin deficiency

By Caroline Dixon, Karen Breen, Sue Robinson, Aine McCormick, and Professor Beverley Hunt OBE

• Challenge: Inherited antithrombin deficiency (ATD) markedly increases VTE risk during pregnancy, but LMWH efficacy depends on antithrombin levels.
• Approach: A single-centre cohort (32 pregnancies, 17 women) adopted anti-Xa-guided LMWH dosing with selective peripartum antithrombin concentrate.
• Outcome: Overall VTE rate was 12.5%, yet no VTE occurred in adherent women receiving anti-Xa–adjusted LMWH. Haemorrhage risk remained acceptable (12.5%, mostly moderate).”

Read the full article in JTH.

Article: Anti-Xa directed low-molecular-weight heparin dosing to reduce the risk of venous thromboembolism in pregnant women with inherited antithrombin deficiency

Authors: Caroline Dixon, Karen Breen, Susan Robinson, Aine McCormick, Beverley J. Hunt

Caroline Dixon and Colleagues on LMWH Dosing to Reduce The Risk of VTE in Pregnant Women With Inherited ATD

Stay updated on all scientific advances in the field of thrombosis with Hemostasis Today.

Aine McCormick Antithrombin Deficiency AT ATD Beverley J. Hunt Caroline Dixon Health Hematology Hemostasis Hemostasis Today JTH Karen Breen LMWH Medicine Pregnancy Susan Robinson thrombosis venous thromboembolism VTE
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