Cedric Hermans Presenting FRONTIER2 Data on Mim8 in Adolescents and Adults with Haemophilia A
Wolfgang Miesbach, Professor of Medicine at Frankfurt University Hospital, shared on LinkedIn:
“What matters most – patient reported outcomes at ASH Cedric Hermans presenting FRONTIER2 data on Mim8 in adolescents and adults with haemophilia A (with and without inhibitors) – and it’s a reminder of what we should have been measuring all along. Not just bleeding control, but how patients actually live.
The numbers:
Treatment burden – 46-62% hit clinically meaningful improvement
Joint pain – 59-95% saw relief depending on where they started
Physical activity – jumped across all groups, 100% in the on-demand cohort
Physical functioning – +4 to +17.6 on the PedsQL scale
But the real story?
88-98% of patients prefer Mim8 over what they were taking before.
Three different PRO measures (Hemo-TEM, PedsQL, JPRS) all pointed the same way. Better experience, better function, less pain. And it held up over the full 52 weeks.
QW vs QM dosing showed similar PRO benefits – patients actually have flexibility that works.
When you ask patients what matters: It’s your life back. Less burden. Less pain. More activity. Those preference numbers speak for themselves”
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