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Nicolas Gendron on The Emerging Role of CLIA in The Diagnosis Strategy for HIT
Nicolas Gendron/LinkedIn
Sep 10, 2025, 22:34

Nicolas Gendron on The Emerging Role of CLIA in The Diagnosis Strategy for HIT

Nicolas Gendron, Research Fellow, Hematologist at Boston Children’s Hospital, shared a proud post on LinkedIn:

”New online publication in Blood VTH, Blood Journals Portfolio
Heparin-induced thrombocytopenia (HIT) is a serious complication of heparin treatments.

Its rapid and reliable diagnosis is essential to adapt management and improve the prognosis of patients.

At the HEGP, we compared the diagnostic performance for the detection of anti-PF4/H antibodies of the HemosIL AcuStar HIT-IgG test (CLIA, Werfen ) with that of our Zymutest HIA IgG reference test (ELISA, HYPHEN BioMed ), in 113 patients suspected of TIH (score 4Ts >3), taking as a reference the result of the platelet function test by radiolabeled serotonin release (RAS).

Excellent sensitivity and specificity of both tests

  • Very few discordant cases among patients with confirmed HIT
  • Overall agreement between the two techniques: 91.2%
  • CLIA has proven to be reliable, fast and efficient

These findings support the use of CLIA as a rapid and relevant diagnostic tool in the diagnosis strategy for HIT

Congratulations to Carla Rial and everyone involved in this great collaborative work!
Shaya Sable, Christine Le Beller, Aurélie Sarthou, Mauge Laetitia, Justine Piazza, Roya Nili Maude Laney, Isabelle Presot Jean-Luc Diehl, Agnès Lillo-Le Louet, Anne Godier, David Smadja, Helley-Russick Dominique
Paris Cardiovascular Research Center – PARCC
Université Paris Cité Faculté de Santé – Université Paris Cité
Université Paris Cité Médecine Greater Paris University Hospitals – AP-HP
Werfen Werfen North America”

Read the full article in Blood VTH.

Article: Evaluation of a chemiluminescent immunoassay IgG anti-PF4/H in the Diagnosis of Heparin-Induced Thrombocytopenia

Authors: Carla Rial, Nicolas Gendron, Christine Le Beller, Shaya Sable, Aurélie Sarthou, Laetitia Mauge, Justine Piazza, Roya Nili, Maude Laney, Isabelle Presot, Jean-Luc Diehl, Anne Godier, Agnès Lillo-Le Louet, David M. Smadja, Dominique Helley

Nicolas Gendron on The Emerging Role of CLIA in The Diagnosis Strategy for HIT

Stay updated on the latest scientific advances in the field of platelet disorders with Hemostasis Today.

Agnès Lillo-Le Louet Anne Godier Aurélie Sarthou Carla Rial Christine Le Beller CLIA David M. Smadja Dominique Helley ELISA Health Hematology HemosIL AcuStar Hemostasis Hemostasis Today Heparin HIA HIT HYPHEN Isabelle Presot Jean-Luc Diehl Justine Piazza Laetitia Mauge Maude Laney Medicine Nicolas Gendron Roya Nili Shaya Sable thrombosis Werfen
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