Danny Hsu: Fascinating Insight into the Cellular Mechanisms of Statins in APLS
Danny Hsu, President of THANZ, reposted from Journal of Thrombosis and Haemostasis (JTH) on LinkedIn:
”Fascinating insight into the cellular mechanisms of statins in APLS.”
Quoting Journal of Thrombosis and Haemostasis (JTH)‘s post:
”Simvastatin competitively inhibits cellular signaling of lipid-binding antiphospholipid antibodies
By Dominika Marova, Paul Frankenbach, Dr. Anne Hollerbach, Susanne Strand, Wolfram Ruf, Karl Lackner, and Nadine Müller Calleja
Antiphospholipid antibodies (aPLs) drive thrombosis and inflammation via endothelial protein C-receptor (EPCR)–mediated binding of lysobisphosphatidic acid (LBPA).
Statins may exert direct anti-APS effects through molecular competition at EPCR–lipid interfaces, not merely via lipid-lowering or pleiotropic vascular actions.”
Read the full article here.
Article: Simvastatin competitively inhibits cellular signaling of lipid-binding antiphospholipid antibodies
Authors: Dominika Marova, Paul Frankenbach, Anne Hollerbach, Susanne Strand, Wolfram Ruf, Karl J. Lackner, Nadine Müller-Calleja
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