Dirk Sibbing: Why CYP2C19 Genetics Matter in Clopidogrel Response
Dirk Sibbing, Cardiologist and Angiologist at Lauterbacher Mill Private Clinic and LMU Munich, shared a post on LinkedIn about recent articles he and his colleagues co-authored, adding:
“Clopidogrel – 2025 ACC/AHA/ACEP/NAEMSP/SCAI ACS Guidelines
While the FDA warning on CYP2C19*2 and reduced response to clopidogrel is clinically highly relevant and the warning itself is still in place, recent AHA/ACC 2025 ACS guidelines missed on providing guidance here for clinicians.
We did so in our commentary in JAHA — Journal of the American Heart Association by providing information and guidance on antiplatelet treatment with clopidogrel.
Genetics matter and may have a significant impact – especially for antiplatelet treatment during and after PCI.”
Title: 2025 ACC/AHA/ACEP/NAEMSP/SCAI Guideline for the Management of Patients With Acute Coronary Syndromes: A Report of the American College of Cardiology/American Heart Association Joint Committee on Clinical Practice Guidelines
Authors: Sunil V Rao, Michelle L O’Donoghue, Marc Ruel, Tanveer Rab, Jaqueline E Tamis-Holland, John H Alexander, Usman Baber, Heather Baker, Mauricio G Cohen, Mercedes Cruz-Ruiz, Leslie L Davis, James A de Lemos, Tracy A DeWald, Islam Y Elgendy, Dmitriy N Feldman, Abhinav Goyal, Ijeoma Isiadinso, Venu Menon, David A Morrow, Debabrata Mukherjee, Elke Platz, Susan B Promes, Sigrid Sandner, Yader Sandoval, Rachel Schunder, Binita Shah, Jason P Stopyra, Amy W Talbot, Pam R Taub, Marlene S Williams
Title: 2025 Acute Coronary Syndrome Guideline: Missing the Boat on CYP2C19 Genotyping
Authors: Larisa H Cavallari, Craig R Lee, Amber L Beitelshees, Jasmine A Luzum, George A Stouffer, Jurriën M ten Berg, Wout W A van den Broek, Naveen L Pereira, Dirk Sibbing, Dominick J Angiolillo
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