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Eric Goffin: Complement Activation Is the Hallmark of Atypical HUS
Eric Goffin/LinkedIn
Oct 28, 2025, 06:53

Eric Goffin: Complement Activation Is the Hallmark of Atypical HUS

Eric Goffin, Head of the Nephrology at Cliniques Universitaires St-Luc, shared on LinkedIn:

”Uncontrolled complement activation: the hallmark of atypical hemolytic uremic syndrome (aHUS).

This rare but severe condition causes microvascular thrombosis, hemolysis, and kidney failure. Understanding why and who is affected is key to saving lives.

A new study from the Belgian cohort of the Global aHUS Registry just brought valuable answers !

  • Massart A. et al., Journal of Nephrology (2025)
  • Key insights:
  • 121 Belgian patients (≈10.4 per million)
  • 58% were women
  • 1 in 3 carried a complement gene variant or anti-CFH antibodies
  • Main genes involved: CFH, C3, and CD46

These real-world data deepen our understanding of aHUS and highlight the importance of personalized diagnostics and targeted complement therapies.”

Read the full article here.

Title: Clinical and genetic characteristics of patients diagnosed with atypical hemolytic uremic syndrome (aHUS): epidemiological data from the Belgian cohort of the Global aHUS Registry

Authors: Annick Massart, Laurent Weekers, Kathleen J. Claes, Tess Van Meerhaeghe, Evelien Snauwaert, Djalila Mekahli, Eric Goffin, Laure Collard, Nathalie Godefroid, Brigitte Adams, Stefan Van Cauwelaert, Koenraad Van Hoeck, Sebastien Block, Imad Al-Dakkak, Karin Dahan, Patrick Stordeur, Johan Vande Walle

Eric Goffin:

Stay updated with Hemostasis Today.

aHUS Annick Massart Atypical Hemolytic Uremic Syndrome Brigitte Adams Complement Activation Djalila Mekahli Eric Goffin Evelien Snauwaert Hematology hemolysis Hemostasis Today Imad Al-Dakkak Johan Vande Walle Karin Dahan Kathleen J. Claes Kidney Failure Koenraad Van Hoeck Laure Collard Laurent Weekers Medicine Nathalie Godefroid Nephrology Patrick Stordeur Sebastien Block Stefan Van Cauwelaert Tess Van Meerhaeghe thrombosis
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