Felix Scholkmann: Serotonin and the Formation of Microvascular Fibrin
Felix Scholkmann, Group Leader, Neurophotonics and Biosignal Processing Research Group at the University Hospital Zuric, shared a post on X about a recent article by Davide Marotta et al., published in Science Immunology, adding:
“Serotonin-driven platelet hyperactivation directly promotes extensive fibrin deposition in the microvasculature.
This finding could be relevant to explain the formation of persistent fibrinaloid microclots.”
Resia Pretorius, Vice-Dean for Research and Postgraduate Students at Stellenbosch University, Faculty of Science, shared Felix Scholkmann‘s post on X, adding:
“This is of great importance as we believe that amyloidogenic platelet debris forms the seeding areas for one of our main microclot complex phenotypes.”
Title: Platelet-derived serotonin drives age-related lung pathology in SARS-CoV-2 infection
Authors: Davide Marotta, Chiara Perucchini, Marta Grillo, Valeria Fumagalli, Pietro Di Lucia, Jordan Rixon, Micol Ravà, Leonardo Giustini, Chiara Malpighi, Giulia D’Uonnolo, Mariangela Scavone, Violette Mouro, Caitlin Abbott, Natalia Stachura-Chyla, Francesco Andreata, Erica Scalambrino, Marigrazia Clerici, Lorena Donnici, Marika Longo Minnolo, Donato Inverso, Raffaele De Francesco, Mauro Gaya, Zaverio M. Ruggeri, Armando Tripodi, Gian Marco Podda, Luca G. Guidotti, Matteo Iannacone, Marco De Giovanni
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