Gurpreet Kaur Sagoo: Diagnosing PNH in Aplastic Anaemia – Looking Beyond the Marrow
Gurpreet Kaur Sagoo, Professor at Armed Forces Medical College, shared a post on LinkedIn about a recent article she and her colleagues co-authored, published in Indian Journal of Hematology and Blood Transfusion, adding:
“Diagnosing PNH in Aplastic Anaemia: Looking Beyond the Marrow
The recognition of Paroxysmal Nocturnal Hemoglobinuria (PNH) clones in patients with aplastic anaemia has transformed our understanding of bone marrow failure syndromes.
Rather than representing distinct entities, aplastic anaemia and PNH are now viewed as disorders that frequently coexist along a clinicopathological spectrum.
The diagnosis of PNH in aplastic anaemia relies on high-sensitivity multiparametric flow cytometry, with particular emphasis on granulocyte and monocyte populations.
Importantly, the absence of overt haemolysis does not exclude the presence of a clinically significant PNH clone. In fact, small clones are commonly identified in aplastic anaemia and may provide evidence of an underlying immune-mediated pathogenesis.
Their detection carries prognostic significance and may predict a more favourable response to immunosuppressive therapy.
For the practising haematopathologist, accurate clone quantification and longitudinal monitoring are essential. Reporting should include clone size across granulocyte, monocyte, and erythroid compartments, while recognising the limitations of red cell analysis in recently transfused patients.”
Title: Diagnosis of Paroxysmal Nocturnal Hemoglobinuria (PNH) in Aplastic Anemia
Authors: Tathagata Chatterjee, Gurpreet Kaur, Ankur Ahuja
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