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Harlinde Peperstraete: From Circuit to Coagulation – Understanding Hemostasis in ECMO
Harlinde Peperstraete/LinkedIn
May 14, 2026, 16:01

Harlinde Peperstraete: From Circuit to Coagulation – Understanding Hemostasis in ECMO

Harlinde Peperstraete, Adjunct Kliniekhoofd at University Hospital Ghent, shared a post on LinkedIn about a recent article by she and her colleagues co-authored, published in Critical Care, adding:

“Very happy and proud to share our latest publication in Critical Care:

‘Extracorporeal life support and Modification Of Hemostasis:

the ELMOH trial:

hemostatic changes during the first 48 h of VV- and VAECMO: a prospective multicenter cohort study’

‘The hemostatic story starts before the circuit does.’

In this prospective multicenter cohort study, we explored hemostatic changes before and during the first 48 hours of VV- and VA-ECMO.

One of the key findings was that patients supported for circulatory failure and those supported for isolated respiratory failure already showed different hemostatic profiles at baseline.

VA-ECMO patients had lower platelet counts and a more hypocoagulable profile early on, while VV-ECMO patients remained relatively hypercoagulable during the first 48 hours.

These findings suggest that early coagulation abnormalities in ECMO patients reflect both the underlying clinical condition and the effects of extracorporeal support.

They support the need for individualized hemostatic monitoring and anticoagulation management.

A heartfelt thank you to my co-authors and collaborators for their dedication, insight, and teamwork:

Harlinde Peperstraete, Korneel Vandewiele, Katrien M. J. Devreese, Paul Massion, Michael Piagnerelli, Matthias Raes, Pieter Depuydt, and Eric Hoste.

This work would not have been possible without the ICU teams, study coordinators, and participating centers involved in patient inclusion, sampling, and data collection.

Because in ECMO, balancing bleeding and thrombosis is never routine, it is personal.”

Title: ExtracorporeaL life support and Modification Of Hemostasis: the ELMOH trial: hemostatic changes during the first 48 h of VV- and VA-ECMO: a prospective multicenter cohort study

Authors: Harlinde Peperstraete, Korneel Vandewiele, Katrien M. J. Devreese, Paul Massion, Michaël Piagnerelli, Matthias Raes, Pieter Depuydt and Eric Hoste
Harlinde Peperstraete

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and Eric Hoste Harlinde Peperstraete Health Hematology Hemostasis Hemostasis News Hemostasis Today Katrien M. J. Devreese Korneel Vandewiele Matthias Raes Medicine Michael Piagnerelli Paul Massion Pieter Depuydt Pieter Depuydt and Eric Hoste
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