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Heghine Khachatryan: New evidance – Antiphospholipid Antibodies and Ischemic Stroke
Heghine Khachatryan/LinkedIn
Sep 14, 2026, 23:49

Heghine Khachatryan: New evidance – Antiphospholipid Antibodies and Ischemic Stroke

Heghine Khachatryan, Editor-in-Chief of Hemostasis Today, Head of Hemophilia and Thrombosis Center at Yeolyan Hematology and Oncology Center, shared a post on LinkedIn about a recent article by Nathan W Watson et al., published in Stroke, adding:

“New evidance | Antiphospholipid Antibodies and Ischemic Stroke

A new systematic review and meta-analysis including 52 studies examined the association between antiphospholipid antibodies (aPL) and ischemic stroke.

Approximately 19.1% of patients with ischemic stroke were aPL-positive.

The presence of aPL was associated with a higher likelihood of a first ischemic stroke (OR 2.93), with the strongest association observed for lupus anticoagulant (OR 6.69).

Importantly, the analysis did not demonstrate a significant increase in recurrent stroke risk among aPL-positive patients.

Clinical perspective

These findings support targeted aPL testing in appropriately selected patients, particularly in:

  • Younger patients with ischemic stroke
  • Cryptogenic stroke
  • Unusual arterial thrombosis
  • Patients with a relevant autoimmune background

At the same time, a single positive aPL result should not be equated with a diagnosis of antiphospholipid syndrome (APS).

Transient or incidental aPL positivity may occur, including in the setting of an acute thrombotic event.

Diagnosis of APS requires the appropriate clinical context, a relevant antibody profile, and confirmation of persistent positivity according to established criteria.

The study reinforces an important principle: aPL positivity is common enough to matter, but interpretation must remain clinically disciplined.”

Title: Prevalence and Clinical Relevance of Antiphospholipid Antibodies in Ischemic Stroke: A Systematic Review and Meta-Analysis

Authors: Nathan W Watson, Syed Bukhari, Sina Rashedi, Mariana Pfeferman, Francisco Ujueta, Bassil Bacare, Brittany N Weber, Mehrdad Zarghami, Yogendra Kanthi, Eric A Secemsky, Jean M Connors, Geoffrey D Barnes, Sacha Uljon, Samuel Z Goldhaber, Jeffrey I Weitz, Karen H Costenbader, Harlan M Krumholz, Gregory Piazza, Mary Cushman, Christopher D Anderson, Mitchell S V Elkind, Behnood Bikdeli

Heghine Khachatryan

Other posts featuring Heghine Khachatryan on Hemostasis Today.

Antiphospholipid Syndrome APS Bassil Bacare Behnood Bikdeli Brittany N. Weber Christopher D. Anderson Eric A. Secemsky Francisco Ujueta Geoffrey D. Barnes Gregory Piazza Harlan M. Krumholz Health Heghine Khachatryan Hematology Hemostasis Hemostasis News Hemostasis Today Jean M. Connors Jeffrey I. Weitz Karen H. Costenbader Mariana Pfeferman Mary Cushman Medicine Mehrdad Zarghami Mitchell S.V. Elkind Nathan W. Watson Sacha Uljon Samuel Z. Goldhaber Sina Rashedi Syed Bukhari Yogendra Kanthi
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