Hossam El Benawi: Do Current Generation CEPD Devices Reduce the Risk of any Stroke During TAVR?
Hossam El Benawi, Senior Clinical Research Fellow of Cardiovascular Medicine at Mayo Clinic, shared a post on LinkedIn about a recent article he and his colleagues co-authored, published in American Heart Journal, adding:
“Current generation CEPD devices during TAVR did not significantly reduce the risk of any stroke, disabling stroke, or all-cause mortality.
Our analysis, Studies included: 8 RCTs (5 filter-based, 3 shield-based), totaling 11,597 patients:
- Any stroke: No reduction with CEPD (RR 0.92; 95% CI 0.75–1.14)
- Disabling stroke: No significant difference (RR 0.80; 95% CI 0.55–1.15)
- MRI-detected lesions: No effect (RR 1.00; 95% CI 0.93–1.07)
- All-cause mortality: No significant difference (RR 1.04; 95% CI 0.71–1.51)
- Trial sequential analysis: Demonstrated conclusive evidence, supporting no benefit of Current generation CEPD.
- Meta-regression: No significant association between stroke risk and patient-level factors (age, sex, diabetes, prior stroke, atrial fibrillation; all p > 0.05)
At least with available data, cumulative evidence appears sufficient to question the predefined benefit thresholds for existing systems.
These findings suggest the lack of routine use of current-generation CEPD in TAVR.”
Title: Cerebral Embolic Protection Devices for Transcatheter Aortic Valve Replacement: A Meta-Analysis and Trial Sequential Analysis
Authors: Hossam Elbenawi, Ibrahim Hassan, Mahmoud Shaaban Abdelgalil, Mariam Hanna, Salma Almotawally, Mahmoud Fayed, Kareem A. Mohamed, Hossam Elnaggar, Louna Abouainain, Belal Mohamed Hamed, Ahmed Ibrahim, Ahmed Al Khatib, Mohamed Elhelw, Ehab Hassan, Mahmoud Eisa, Morad Zaaya, Ramzi Ibrahim, Andrew M. Goldsweig, Marwan Saad, Fernando Alfonso, Mohamad Alkhouli, Islam Y. Elgendy
More posts featuring Hossam El Benawi on Hemostasis Today.
-
Apr 27, 2026, 14:55Diana Domenica Bruno։ Flying During Pregnancy Is Generally Safe, but Physiologic Changes Require Thoughtful Planning
-
Apr 27, 2026, 14:46Mariam Swidan: Hemolytic Anemia – Disease Overview
-
Apr 27, 2026, 14:39Talha Aman: How CABG Works to Restore Blood Flow to the Heart
-
Apr 27, 2026, 14:38Olivia Romero Lux: Raising Awareness of Bleeding Disorders in Women
-
Apr 27, 2026, 14:37Mansi Kala: Improving Patient Care in Hematological Disorders Through Diagnostic Challenges Research at ISTH 2026
-
Apr 27, 2026, 14:35Sara Moscatelli: Apixaban in Children is Not Just Safe, But Biologically Active
-
Apr 27, 2026, 14:33Anusha Narla: Understanding Drug-Food Interaction – Levithyroxine
-
Apr 27, 2026, 14:32Juha Kotimaa։ New Insights into How APAC Shapes Complement Activation and Inflammation
-
Apr 27, 2026, 14:31Tushar Pandey: When Low Platelets Are Not ITP