Jacinto López Sagaseta: Solving the Structural Puzzle of FVIIa–EPCR Interaction
Jacinto López Sagaseta, Lead Consultant, Protein Research and Discovery at Phase Solution Protein Discovery SL, shared a post on LinkedIn about a recent article by Vaheh Oganesyan, published in Journal of Biological Chemistry adding:
“Recombinant factor VIIa (rFVIIa) is an important clinical intervention for severe bleeding, but some aspects associated with its mechanism of action have remained unresolved.
In 2007, several groups reported that FVIIa directly binds EPCR, an endothelial receptor, with consequences for the hemostatic effect of rFVIIa.
Despite extensive investigation, the structural basis of this interaction had remained elusive.
In this work, we report the experimental structure of the FVIIa Gla domain bound to EPCR, providing a missing structural piece in the study of FVIIa.
This is a particularly intricate protein complex, as it involves several residues of y-carboxyglutamate-an unusual yet naturally occurring amino acid, divalent ions, and a phospholipid molecule.
As such, it may also represent an interesting case for AI-based protein structure prediction and associated computational resources.
We are pleased to place this work in the context of the earlier study (2002) by Ogannesyan et al, who solved the structure of the protein C Gla domain bound to the same receptor, a landmark contribution to the structural biology of coagulation.
We would also like to thank the staff of the Xaira and Xaloc beamlines at the ALBA Synchrotron.
Further details can be found in the publication”
Title: The Crystal Structure of the Endothelial Protein C Receptor and a Bound Phospholipid
Authors: Vaheh Oganesyan, Natalia Oganesyan, Simon Terzyan, Dongfeng Qu, Zbigniew Dauter, Naomi L. Esmon, Charles T. Esmon
Stay updated on all scientific advances with Hemostasis Today.
-
May 22, 2026, 12:25Shehab Mohamed: Exploring the Emerging Link Between JAK2 Mutations and Thoracic Aortic Aneurysms
-
May 22, 2026, 11:52Prakash W. Kamat: Highlighting the Role of Physical Activity in Hemophilia Management
-
May 22, 2026, 11:43Mohamed Hanafy Morsy: Understanding Hemochromatosis – Genetics Made Simple
-
May 22, 2026, 10:23Rucha Patil: Insights from The National Haemophilia Conclave 2026
-
May 22, 2026, 10:11Narat Srivali: New Systematic Review and Meta-Analysis on Glucocorticoid Therapy and The Risk of VTE
-
May 22, 2026, 10:02Greta Mulders: Nursing Leadership in Haemophilia Gene Therapy
-
May 22, 2026, 08:45Dirk Sibbing: Ethnicity and Antiplatelet Therapy Outcomes in CCS
-
May 22, 2026, 08:35Jason Brandon: On Lyophilized Hemostatic Supplementation at Simmons Research Day 2026
-
May 22, 2026, 08:28Inconsistent D-Dimer Assay Reporting in VTE Studies – JTH