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Jamie Madrigal And The Team – Mathematical Analysis Of Emicizumab: Affinity-Driven Complex Formation And Lipid-Surface Reactions
Jamie Madrigal/LinkedIn
Oct 10, 2025, 12:17

Jamie Madrigal And The Team – Mathematical Analysis Of Emicizumab: Affinity-Driven Complex Formation And Lipid-Surface Reactions

 

Jamie Madrigal, Scientist at Certara, shared a post by Journal of Thrombosis and Haemostasis on LinkedIn:

”Excited to share that my PhD research on emicizumab was recently published.”

Quoting Journal of Thrombosis and Haemostasis’s post:

”Mathematical analysis of emicizumab: affinity-driven complex formation and lipid-surface reactions

This study used mathematical modeling and biochemical assays to dissect how emicizumab, a bispecific antibody bridging activated factor IXa and factor X, functions differently from factor VIII. It revealed that high emicizumab levels inhibit factor X activation via tissue factor pathway due to reduced lipid surface binding but enhance factor IXa-dependent activation of factor X on lipid surfaces. The model provides kinetic estimates and explains emicizumab’s mechanism of enhancing coagulation through lipid-surface interactions.

Read this paper here.

Title: Mathematical analysis of emicizumab: affinity-driven complex formation and lipid-surface reactions

Authors: Jamie Madrigal, Dougald Monroe, Suzanne Sindi, Karin Leiderman”

Emicizumab

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American Thrombosis and Hemostasis Network (ATHN) Dougald Monroe Emicizumab Health Hematology Hemostasis Hemostasis Today International Society on Thrombosis and Haemostasis ISTH Jamie Madrigal Journal of Thrombosis and Haemostasis JTH Karin Leiderman Medicine Suzanne Sindi
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