Jamie Madrigal And The Team – Mathematical Analysis Of Emicizumab: Affinity-Driven Complex Formation And Lipid-Surface Reactions
Jamie Madrigal, Scientist at Certara, shared a post by Journal of Thrombosis and Haemostasis on LinkedIn:
”Excited to share that my PhD research on emicizumab was recently published.”
Quoting Journal of Thrombosis and Haemostasis’s post:
”Mathematical analysis of emicizumab: affinity-driven complex formation and lipid-surface reactions
This study used mathematical modeling and biochemical assays to dissect how emicizumab, a bispecific antibody bridging activated factor IXa and factor X, functions differently from factor VIII. It revealed that high emicizumab levels inhibit factor X activation via tissue factor pathway due to reduced lipid surface binding but enhance factor IXa-dependent activation of factor X on lipid surfaces. The model provides kinetic estimates and explains emicizumab’s mechanism of enhancing coagulation through lipid-surface interactions.
Read this paper here.
Title: Mathematical analysis of emicizumab: affinity-driven complex formation and lipid-surface reactions
Authors: Jamie Madrigal, Dougald Monroe, Suzanne Sindi, Karin Leiderman”
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