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Laura Girardi on Anticoagulant Treatment for Isolated Distal DVT: Finally Our Official Paper Is Out!
Laura Girardi/X
Oct 5, 2025, 11:54

Laura Girardi on Anticoagulant Treatment for Isolated Distal DVT: Finally Our Official Paper Is Out!

Laura Girardi, Clinical and Research Thrombosis Fellow at The Ottawa Hospital, shared on LinkedIn:

”Finally our official paper is out!

An updated systematic review with meta-analysis on management of isolated distal DVT (IDDVT).

Thanks to my fabulous colleagues to have made it possible.

Efficacy outcomes (recurrent DVT, PE, proximal progression of IDDVT and PTS) and safety outcomes (major bleeding and CRNMB) are mainly presented depending on different approaches:
1. No anticoagulation
2. Short duration of anticoagulation (<6 weeks)
3. Long duration (6-12 weeks)
4. Extended-anticoagulation (>12 weeks)

  • Patients receiving short courses of anticoagulation had higher risk of recurrent VTE (RR=2.72; 95% CI: 1.19-6.23) and proximal progression (RR=3.86; 95% CI: 1.77-8.43) than patients receiving long anticoagulation, with similar bleeding risk in patients with IDDVT.
  • Anticoagulation seemed associated with lower risk of recurrent VTE and proximal progression, and similar bleeding risk compared to no anticoagulant treatment.
  • The incidence of PTS was 30% in untreated patients, 11% in short, and 0% in long anticoagulation.
  • Long-term treatment duration appeared to be more effective.

Please find more details (e.g. dose and type of anticoagulation, baseline patients’ risks, etc.) in the full text!”

Read the full article in Haematologica.

Article: Anticoagulant treatment for isolated distal deep vein thrombosis: a systematic review and meta-analysis

Authors: Matteo Guarascio, Emanuele Valeriani, Laura Girardi, Matteo Candeloro, Arianna Pannunzio, Ilaria Maria Palumbo, Marcello Di Nisio, Walter Ageno

Laura Girardi on Anticoagulant Treatment for Isolated Distal DVT: Finally Our Official Paper Is Out!

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Anticoagulation Arianna Pannunzio CRNMB DVT Emanuele Valeriani Haematologica Health Hematology Hemostasis Hemostasis Today IDDVT Ilaria Maria Palumbo Laura Girardi Marcello Di Nisio Matteo Candeloro Matteo Guarascio Medicine PE PTS thrombosis VTE Walter Ageno
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