Lucy Rutten: An Important Mechanistic Insight Into Future Vaccine Safety
Lucy Rutten, Senior Scientist at Leiden University, shared on LinkedIn about a recent article she and her colleagues co-authored, adding:
”Proud to share our recent publication in The New England Journal of Medicine.
This international collaboration began in the early phase of investigating rare cases of vaccine-induced immune thrombocytopenia and thrombosis (VITT) following adenoviral vector–based COVID-19 vaccination.
In this study, we elucidate how antibodies initially directed against adenoviral core protein VII can, in rare instances, cross-react with platelet factor 4 (PF4), a key clotting factor, due to a specific somatic mutation (K31E) in the antibody.
These findings provide important mechanistic insight into pathogenesis and future vaccine safety.
It has been a privilege to contribute to this long-standing and highly collaborative effort.”
Title: Adenoviral Inciting Antigen and Somatic Hypermutation in VITT
Authors: Jing Jing Wang, Linda Schönborn, Theodore E. Warkentin, Luisa Müller, Thomas Thiele, Lena Ulm, Uwe Völker, Sabine Ameling, Sören Franzenburg, Lars Kaderali, Ana Tzvetkova, Alex Colella, Tim Chataway, Chee Wee Tan, Bridie Armour, Alexander Troelnikov, Lucy Rutten, James McCluskey, Roland Zahn, Tom P. Gordon, Andreas Greinacher
Read the Full Article on NEJM
Stay updated on all scientific advances with Hemostasis Today.
-
May 24, 2026, 12:04Kalpana Gupta Shekhawat: Ferritin Is More Than an Iron Marker
-
May 24, 2026, 11:50Peter Zdziarski: Making Rare Disease Research More Human
-
May 24, 2026, 11:39Bram Berkelmans: Donating with a View
-
May 24, 2026, 11:28Ratiporn Chinthammit: A Meaningful Exchange in aHUS and PNH Education
-
May 24, 2026, 11:17Mary Ann Sromoski: Transfusion Medicine and Patient Blood Management in Practice
-
May 24, 2026, 07:45Thierry Burnouf: Advances in Platelet Membrane-Coated Nanoparticles for Targeted Therapeutics and Regenerative Medicine
-
May 24, 2026, 07:39Shamala Thilarajah: Our Team Receives the NMRC Transition Award for NEUROACT-Stroke
-
May 24, 2026, 05:48Yazan Abou-Ismail: Contributing to the Future of von Willebrand Disease Management
-
May 24, 2026, 05:47Ali AlBahar: The Immunologic Complexity Behind ABO Blood Grouping