Maité Mulkers: Time is Brain, and One Reason is That a Thrombus Develops Over Time
Maité Mulkers, PHD Researcher at LMU Klinikum München, shared a post on LinkedIn:
“Time is brain, and one reason is that a thrombus develops over time.
I had the opportunity to comment on the work of Zang and colleagues, describing how blood clots become more stiff and harder to treat within hours and over days.
The culprit?
Serpin B3-positive neutrophils, which upregulate TGF-β1 and promote collagen deposition.
More on this neutrophil-driven remodeling of thrombi, and the potential of Serpin B3 as a therapeutic target and our commentary with Rainer Kaiser.”
Title 1: Pathogenic role of serpin B3-positive neutrophils in reinforcing thrombus stiffening during ischemic stroke
Authors: Jiankun Zang, Aijun Lu, Bing Yang, Na Tan, Qihuan Liu, Liping Wei, Ying Liang, Sijie Zhou, Zefeng Tan, Xiufeng Xin, Shengwen He, Panwen Wu, Yufeng Li, Zhifeng Xu, Xuanlin Su, Hongcheng Mai, Anding Xu, Dan Lu
Read the Full Article on Blood
Title 2: The clot stiffens: neutrophil serpin B3 in ischemic stroke
Authors: Maité Mulkers, Rainer Kaiser
Read the Full Article on Blood
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