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Maité Mulkers: Time is Brain, and One Reason is That a Thrombus Develops Over Time
Rainer Kaiser and Maité Mulkers/LinkedIn
Jun 23, 2026, 17:33

Maité Mulkers: Time is Brain, and One Reason is That a Thrombus Develops Over Time

Maité Mulkers, PHD Researcher at LMU Klinikum München, shared a post on LinkedIn:

“Time is brain, and one reason is that a thrombus develops over time.

I had the opportunity to comment on the work of Zang and colleagues, describing how blood clots become more stiff and harder to treat within hours and over days.

The culprit?

Serpin B3-positive neutrophils, which upregulate TGF-β1 and promote collagen deposition.

More on this neutrophil-driven remodeling of thrombi, and the potential of Serpin B3 as a therapeutic target and our commentary with Rainer Kaiser.”

Title 1: Pathogenic role of serpin B3-positive neutrophils in reinforcing thrombus stiffening during ischemic stroke

Authors: Jiankun Zang, Aijun Lu, Bing Yang, Na Tan, Qihuan Liu, Liping Wei, Ying Liang, Sijie Zhou, Zefeng Tan, Xiufeng Xin, Shengwen He, Panwen Wu, Yufeng Li, Zhifeng Xu, Xuanlin Su, Hongcheng Mai, Anding Xu, Dan Lu

Read the Full Article on Blood

Maité Mulkers

Title 2: The clot stiffens: neutrophil serpin B3 in ischemic stroke

Authors: Maité Mulkers, Rainer Kaiser

Read the Full Article on Blood

Maité Mulkers

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Aijun Lu Anding Xu Australasian Stroke Academy Bing Yang Blood Collagen Dan Lu Health Hematology Hemostasis News Hemostasis Today Hongcheng Mai Ischemic stroke Jiankun Zang Liping Wei Maité Mulkers Medicine Na Tan Neutrophils Panwen Wu Qihuan Liu Rainer Kaiser Serpin B3 Shengwen He Sijie Zhou thrombi thrombosis thrombus Xiufeng Xin Xuanlin Su Ying Liang Yufeng Li Zefeng Tan Zhifeng Xu
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