Michael Wilkinson: How Lp(a) Shapes Coronary Plaque and Cardiovascular Risk
Michael Wilkinson, Associate Professor of Medicine at UC San Diego Health, shared a post on LinkedIn about a recent article he and his colleagues co-authored, published in Current Atherosclerosis Reports, adding:
“Our timely, state-of-the-art review now published in Springer Nature Current Atherosclerosis Reports:
‘The Evolving Role of Coronary Artery Imaging in Assessing Cardiovascular Risk from Lipoprotein(a).’
- CAC scoring shows associations with Lp(a) incidence and progression, though findings across studies remain inconsistent.
- CCTA offers the most detailed noninvasive assessment, linking elevated Lp(a) to greater plaque prevalence, multivessel disease, and high-risk features like low-attenuation plaque, positive remodeling, and napkin-ring sign.
- Invasive imaging (OCT, IVUS) reinforces this, with elevated Lp(a) tied to thin-cap fibroatheroma, lipid-rich plaque, and greater atheroma progression over time.
There’s still a lot to learn about how Lp(a) uniquely shapes plaque biology and risk – this is a critical area for Lp(a) research in the coming years.”
Title: The Evolving Role of Coronary Artery Imaging in Assessing Cardiovascular Risk from Lipoprotein(a)
Authors: Michael T. Savides, Harpreet S. Bhatia, Inna Kuznetsova, Michael J. Wilkinson
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