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Nishant Rajendra Tiwari: Hereditary TTP With the Same ADAMTS13 Variants but Strikingly Different Disease Courses
Nishant Rajendra Tiwari/X
Sep 22, 2026, 23:58

Nishant Rajendra Tiwari: Hereditary TTP With the Same ADAMTS13 Variants but Strikingly Different Disease Courses

Nishant Rajendra Tiwari, Chief Hematology-Oncology Fellow at OU Health Stephenson Cancer Center, shared a post on X about a recent article he and his colleagues co-authored, published in Pediatrics, adding:

“Excited to share our new case series in Pediatrics (out today): three siblings with hereditary TTP (hTTP) — same ADAMTS13 variants, strikingly different disease courses — all diagnosed decades later.

Key message:

A newborn with Coombs-negative jaundice with severe thrombocytopenia and hemolytic anemia should prompt you to think hTTP, not just hemolytic disease of the newborn. Early recognition can spare kids exchange transfusions and years of workups.

Proud of the work of our team, but even more grateful to my mentors Dr. George and Dr. Ibrahimi, for giving me the wings to fly and pushing me further than I ever dreamt.

Thanks to our amazing division, and fellowship program leadership, attendings, who go out of the way to inspire, help and teach the trainees.”

Title: Hereditary TTP and Hemolytic Anemia in Newborns

Authors: Christa I. DeVette, Nishant Tiwari, James N. George, Kisha A. Beg, Sami Ibrahimi, Rose M. Doolittle

Nishant Rajendra Tiwari

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ADAMTS13 anemia Blood Christa I. DeVette Health Hematology Hemolytic anemia Hemostasis Hemostasis News Hemostasis Today Hereditary TTP hTTP James N. George Kisha A. Beg Medicine Nishant Rajendra Tiwari Nishant Tiwari Pediatrics Rose M. Doolittle Sami Ibrahimi severe thrombocytopenia TTP
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