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Preoperative Platelet Transfusion: Outcomes vs Guideline Thresholds
Anna Homeniuk/LinkedIn
Dec 11, 2025, 23:40

Preoperative Platelet Transfusion: Outcomes vs Guideline Thresholds

José Antonio García Erce, Director of the Donation Center, Navarre Health Service (Osasunbidea), shared on LinkedIn:

”Preoperative platelet transfusion in cancer surgery: Outcomes across and above guideline thresholds.

Preoperative platelet transfusion was associated with increased postoperative morbidity and mortality in a 8,800 patients surgical oncology cohort!

Importante trabajo multicéntrico, presentado el pasado día 7 en Orlando en el 67th Congreso de la American Society of Hematology, en uno de los Simposium de Transfusion, bajo el elegante título de Blood Transfusion: Transfusion Frontlines: “Research Driving Safer, Smarter Care” (¡qué bueno e importante título).

Los resultados refuerzan la necesidad de un PBM que incluya las plaquetas. La optimización de los pacientes no sólo es de la cifra de hemoglobina, de la hashtag#coagulación, o de la tolerancia a la anemia, también debemos tratar la trombocitopenia y la trombocitopatía, pero sin necesidad de transfusiones

The authors performed a retrospective, multicenter cohort study of 8,805 adults with active malignancy undergoing surgery under anesthesia from January 1, 2010, to January 1, 2025.

Results: After matching, 3,192 patients in each <50 × 10⁹/L group and 5,613 in each 50–100 × 10⁹/L group were analyzed. In the <50 × 10⁹/L stratum, preoperative platelet transfusion was associated with higher 30-day mortality compared with no transfusion (16.4% vs 11.7%, p<0.001).
– Transfused patients had greater ICU admission rates (12.0% vs 8.7%, p<0.001), more cerebral infarctions (3.9% vs 2.6%) and myocardial infarctions (3.3% vs 2.1%), and substantially more acute kidney failure (24.9% vs 16.8%, p<0.001).
– The likelihood of receiving additional platelet transfusions within 1–3 days postoperatively was markedly higher among transfused patients (27.0% vs 5.1%).

Conclusions: In this large, propensity-matched surgical oncology cohort, preoperative platelet transfusion was associated with increased postoperative morbidity and mortality both below and above current guideline thresholds…”

Read the full abstract here.

Title: Preoperative platelet transfusion in cancer surgery: Outcomes across and above guideline thresholds

Authors: Fatma Yilmaz, Jake Fanizza, Salih Akgun, Abdullah Aktas, Zeynep Yilmaz, Bugra Zengin, Medina Esenbekova, Anna Homeniuk, Anas Atras

Platelet Transfusion

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Abdullah Aktas American Society of Hematology Anas Atras Anna Homeniuk ASH ASH2025 ASH25 Bugra Zengin Fatma Yilmaz Health Hematology Hemostasis Hemostasis Today Jake Fanizza José Antonio García Erce Medicine Medina Esenbekova Navarre Health Service Platelet transfusion Preoperative Platelet Transfusion Salih Akgun thrombosis Zeynep Yilmaz
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