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Roberta Gualtierotti: How Do Sex and Gender Influence VTE in Patients with Cancer?
Photo: expertise.unimi.it
Mar 10, 2026, 12:39

Roberta Gualtierotti: How Do Sex and Gender Influence VTE in Patients with Cancer?

Roberta Gualtierotti, Associate Professor of Internal Medicine at the University of Milan, posted on LinkedIn about a recent article she and her colleagues co-authored, adding:

”Cancer-associated thrombosis (CAT) remains one of the leading causes of morbidity and mortality in oncology.

Yet one important dimension of risk is still insufficiently explored: sex and gender differences.

How do sex and gender influence venous thromboembolism (VTE) in patients with cancer?

Men generally show a higher overall incidence of cancer-associated VTE.

  • Women may experience earlier thrombotic events, often related to anticancer therapies.
  • Biological differences in coagulation and inflammation may contribute to these patterns, although the underlying mechanisms are still not fully understood.
  • Sex-related disparities also appear in treatment complications, including bleeding risk and abnormal uterine bleeding in anticoagulated women of reproductive age.
  • In hematologic malignancies, evidence on sex differences in thrombosis remains limited and inconsistent.

In addition, gender-related inequalities in clinical trial participation still affect the interpretation of available data.

Overall, current evidence supports sex as a clinically relevant modifier of cancer-associated thrombosis risk.

Advancing research that systematically integrates sex- and gender-informed analyses and sex-stratified reporting will be essential to improve mechanistic understanding and support precision medicine in thrombosis and oncology.”

Title: Sex Differences in Cancer-Associated Thrombosis

Authors: Andrea Giachi, Davide Santagata, Addolorata Truma, Andrea Artoni, Paolo Bucciarelli, Luca Valenti, Cihan Ay, Roberta Gualtierotti

Read the Full Article on International Journal of Molecular Sciences

Roberta Gualtierotti: How Do Sex and Gender Influence VTE in Patients with Cancer?

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Addolorata Truma Andrea Artoni Andrea Giachi cancer Cancer Associated Thrombosis CAT Cihan Ay Davide Santagata DVT gender inequalities Health Hematology Hemostasis Hemostasis News Hemostasis Today Luca Valenti Medicine OncoDaily Paolo Bucciarelli Roberta Gualtierotti thrombosis VTE
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