Roberta Gualtierotti: How Do Sex and Gender Influence VTE in Patients with Cancer?
Roberta Gualtierotti, Associate Professor of Internal Medicine at the University of Milan, posted on LinkedIn about a recent article she and her colleagues co-authored, adding:
”Cancer-associated thrombosis (CAT) remains one of the leading causes of morbidity and mortality in oncology.
Yet one important dimension of risk is still insufficiently explored: sex and gender differences.
How do sex and gender influence venous thromboembolism (VTE) in patients with cancer?
Men generally show a higher overall incidence of cancer-associated VTE.
- Women may experience earlier thrombotic events, often related to anticancer therapies.
- Biological differences in coagulation and inflammation may contribute to these patterns, although the underlying mechanisms are still not fully understood.
- Sex-related disparities also appear in treatment complications, including bleeding risk and abnormal uterine bleeding in anticoagulated women of reproductive age.
- In hematologic malignancies, evidence on sex differences in thrombosis remains limited and inconsistent.
In addition, gender-related inequalities in clinical trial participation still affect the interpretation of available data.
Overall, current evidence supports sex as a clinically relevant modifier of cancer-associated thrombosis risk.
Advancing research that systematically integrates sex- and gender-informed analyses and sex-stratified reporting will be essential to improve mechanistic understanding and support precision medicine in thrombosis and oncology.”
Title: Sex Differences in Cancer-Associated Thrombosis
Authors: Andrea Giachi, Davide Santagata, Addolorata Truma, Andrea Artoni, Paolo Bucciarelli, Luca Valenti, Cihan Ay, Roberta Gualtierotti
Read the Full Article on International Journal of Molecular Sciences
Stay updated on all scientific advances with Hemostasis Today.
-
Oct 9, 2026, 10:40What New U.S. Data Reveal About GT – Glanzmann’s Research Foundation
-
Oct 9, 2026, 10:32Anjali Pandey: The Morphologic Clues to MDS With del(5q)
-
Oct 9, 2026, 10:13Reza Shojaei: 5 Leadership Responsibilities for a Sustainable Plasma Ecosystem
-
Oct 9, 2026, 08:38Johannes Gratz: Perioperative Care in Factor VII Deficiency – Treating the Patient, Not the Number
-
Oct 9, 2026, 08:28Ghanim Fajish: Vascular Cells May Retain a Prothrombotic Memory of Oxidative Stress
-
Oct 9, 2026, 07:43Mehmet Cilingiroglu: The First Diagnosis of Coronary Thrombosis in a Living Patient
-
Oct 9, 2026, 07:21Federico Ravaioli: 40 kPa Spleen Stiffness May Help Avoid Endoscopy in Chronic PVT
-
Oct 9, 2026, 07:00Danny Reardon: Closing the Global Awareness Gap on Blood Clots
-
Oct 9, 2026, 00:54Mary Catherine Moffett: Advancing Advocacy Together – Highlights from the Sanofi Bleeding Disorders Summit