Soumya Mukherjee on Amyloid-β Isoform Modifications in CAA and Alzheimer’s
Soumya Mukherjee, Assistant Professor at Washington University in St. Louis, shared on LinkedIn:
”Very happy to share our recent publication in Journal of Neurochemistry
Huge congratulations for the first authors Srinivas Koutarapu and Kaleigh Filisa Roberts for summarzing how distinct Aβ modifications (PTMs) from human postmortem brain tissues could help us distinguish between vascular Aβ deposits in CAA and parenchymal plaques in AD.
We found Aβ heterogenity at both the N-terminus and C-terminus along with structral PTMs.
We found C-terminus truncations are quite common feature in moderate-severe CAA, while N-terminus truncations are more common in plaques.
The strucutral changes arise from their respective protofibrilar architecture of the amyloid.
We thank The Tracy Family SILQ (SILQ) center for funding, resoruces and Knight ADRC staff and tissue biospecimen resources without which this study would not have been possible.
Thank you for the great collaboration Katherine Schwetye, Jogender Mehla, Gregory Zipfel, Randall Bateman, Chihiro Sato.
Our study has potential implications for biomarker development for early CAA detection and therapeutic targeting of vascular versus parenchymal Aβ.”
Read the full article here.
Article: Post-Translational Modifications Distinguish Amyloid-β Isoforms in Cerebral Amyloid Angiopathy and Alzheimer’s Disease
Authors: Srinivas Koutarapu, Kaleigh F. Roberts, Reid A. Coyle, Jogender Mehla, Chihiro Sato, Gregory J. Zipfel, Randall J. Bateman, Katherine E. Schwetye, Soumya Mukherjee
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