July Issue is Now Live – The Lancet Haematology
The Lancet Haematology shared a post on LinkedIn:
“July Issue Now Live!
This month’s editorial explores haematology’s role in epidemic preparedness. The Bundibugyo virus outbreak is a reminder that no medical specialty can afford to look away.
Our July cover by Vito Ansaldi is inspired by a Viewpoint from Ariela Marshall (University of Minnesota) and colleagues advocating for institutional recognition of the value of classical haematology consultation and support for classical haematologists pursuing inpatient-focused careers.
This issue features:
Epcoritamab monotherapy for DLBCL
This phase 2 trial assessed fixed-duration epcoritamab monotherapy versus epcoritamab with lenalidomide in older adults with newly diagnosed diffuse large B-cell lymphoma.
In stage 1, complete response rates were 63·6% (95% CI 47·8–77·6) and 45·5% (30·4–61·2), respectively; across both stages, 57·6% (44·8–69·7; 38 of 66 patients) achieved complete response with monotherapy. Umberto Vitolo (Candiolo Cancer Institute IRCCS) and colleagues.
Inotuzumab ozogamicin for paediatric B-cell ALL
This phase 1–2 trial evaluated inotuzumab ozogamicin in children with CD22-positive very high-risk first B-cell acute lymphoblastic leukaemia relapse.
Among the first 31 enrolled patients, 22 responded (overall response rate 71%, 80% CI 58–82); all had at least one grade 3–4 haematological laboratory abnormality. Erica Brivio (Prinses Máxima Centrum voor kinderoncologie) and colleagues.
Patient-reported AEs after CAR T-cell therapy in B-cell lymphomas
This observational study compared short-term patient-reported symptomatic AEs in patients with aggressive B-cell lymphomas treated with CAR T-cell therapy.
Prevalence exceeded 50% across 12 of 19 symptoms examined, with physicians frequently under-reporting. Fabio Efficace (Fondazione GIMEMA – Franco Mandelli Onlus) and colleagues.
Apixaban for VTE in paediatric patients
This randomised, descriptive study showed that recurrent venous thromboembolism occurred in four (2·6% [95% CI 0·8–6·7]) of 155 patients assigned to apixaban and two (2·7% [0·2–9·9]) of 74 assigned to standard of care, with no major bleeding events.
Leonardo R Brandão (The Hospital for Sick Children) and colleagues.
A comment on this study by Elena Campello and Paolo Simioni
Recommendations from the EBMT Practice Harmonisation and Guidelines Committee on autologous and allogeneic HCT in adult patients with Hodgkin lymphoma. Ali Bazarbachi, Anna Sureda Balari et al.
A Review on female reproductive health—what the classical haematologist needs to know. Bethany Samuelson Bannow (Cleveland Clinic) et al.
In Focus section:
- Securing global supply of human hyperimmune immunoglobulins by Thierry Burnouf et al.
- Sharing the history of blood through patients’ stories by Peter Ranscombe.”
Stay updated on all scientific advances with Hemostasis Today.
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