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Wolfgang Miesbach: Hidden Proteins Discovered in the Human Genome
Wolfgang Miesbach/LinkedIn
May 8, 2026, 14:52

Wolfgang Miesbach: Hidden Proteins Discovered in the Human Genome

Wolfgang Miesbach, Professor of Medicine at Frankfurt University Hospital, shared a post on LinkedIn about a recent article by Eric W. Deutsch et al., published in Nature, adding:

“Hidden Proteins Discovered in the Human Genome.

A landmark Nature study reveals ~1,800 newly detected microproteins – expanding what we thought we knew about human biology:

Before: ~20,000 known protein-coding genes

Now: 1,800 plus additional ‘microproteins’ detected – too small to find with traditional methods

How They Were Found

  • Mass spectrometry: 3.5 billion spectra analyzed
  • Immunopeptidomics: Detected proteins displayed on cell surfaces (240M spectra)
  • CRISPR screening: Proved some are essential for cell survivals

Why This is Important

  • Cancer immunotherapy: These microproteins appear on tumor cells – new treatment targets
  • Drug development: Some control cell division and DNA repair
  • Genetic disease: May explain conditions with no known causes

New Category: ‘Peptideins’
Proteins we can now detect but don’t fully understand yet – opening new research frontiers”

Title: Expanding the human proteome with microproteins and peptideins

Authors: Eric W. Deutsch, Leron W. Kok, Jonathan M. Mudge, Cristian F. Valls, Irwin Jungreis, Jorge Ruiz-Orera, Zhi Sun, Ulrike Kusebauch, Ivo Fierro-Monti, Jennifer G. Abelin, M. Mar Alba, Julie L. Aspden, Sreejan Bandyopadhyay, Kaushik Banerjee, Pavel V. Baranov, Ariel A. Bazzini, Francis Bourassa, Elspeth A. Bruford, Lorenzo Calviello, Steven A. Carr, Anne-Ruxandra Carvunis, Sonia Chothani, Jim Clauwaert, Kellie Dean, Pouya Faridi, Adam Frankish, Amy Goodale, Thomas Green, Norbert Hubner, Nicholas T. Ingolia, Manolis Kellis, Michele Magrane, Maria Jesus Martin, Thomas F. Martinez, Gerben Menschaert, Uwe Ohler, Sandra Orchard, Alisa Potter, Owen J. L. Rackham, Matthew G. Rees, David E. Root, Jennifer A. Roth, Xavier Roucou, Fernando J. Sialana, Sarah A. Slavoff, Michał I. Świrski, Jack A. S. Tierney, Félix-Antoine Trifiro, Eivind Valen, Valeriia Vasylieva, Aaron Wacholder, Shengbo Wang, Li Wang, Jonathan S. Weissman, Wei Wu, Zhi Xie, Jyoti S. Choudhary, Michal Bassani-Sternberg, Juan Antonio Vizcaíno, Nicola Ternette, Marie A. Brunet, Robert L. Moritz, John R. Prensner and Sebastiaan van Heesch

Wolfgang Miesbach

Other posts featuring Wolfgang Miesbach on Hemostasis Today.

 

Aaron Wacholder Adam Frankish Alisa Potter Amy Goodale Anne-Ruxandra Carvunis Ariel A. Bazzini Cristian F. Valls David E. Root Eivind Valen Elspeth A. Bruford Eric W. Deutsch Félix-Antoine Trifiro Fernando J. Sialana Francis Bourassa Gerben Menschaert Health Hematology Hemostasis Hemostasis News Hemostasis Today Irwin Jungreis Ivo Fierro-Monti Jack A. S. Tierney Jennifer A. Roth Jennifer G. Abelin Jim Clauwaert John R. Prensner Jonathan M. Mudge Jonathan S. Weissman Jorge Ruiz-Orera Juan Antonio Vizcaíno Julie L. Aspden Jyoti S. Choudhary Kaushik Banerjee Kellie Dean Leron W. Kok Li Wang Lorenzo Calviello M. Mar Alba Manolis Kellis Maria Jesus Martin Marie A. Brunet Matthew G. Rees Medicine Michal Bassani-Sternberg Michał I. Świrski Michele Magrane Nicholas T. Ingolia Nicola Ternette Norbert Hubner Owen J. L. Rackham Pavel V. Baranov Pouya Faridi Robert L. Moritz Sandra Orchard Sarah A. Slavoff Sebastiaan van Heesch Shengbo Wang Sonia Chothani Sreejan Bandyopadhyay Steven A. Carr Thomas F. Martinez Thomas Green Ulrike Kusebauch Uwe Ohler Valeriia Vasylieva Wei Wu Wolfgang Miesbach Xavier Roucou Zhi Sun Zhi Xie
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