Wolfgang Miesbach: Hidden Proteins Discovered in the Human Genome
Wolfgang Miesbach, Professor of Medicine at Frankfurt University Hospital, shared a post on LinkedIn about a recent article by Eric W. Deutsch et al., published in Nature, adding:
“Hidden Proteins Discovered in the Human Genome.
A landmark Nature study reveals ~1,800 newly detected microproteins – expanding what we thought we knew about human biology:
Before: ~20,000 known protein-coding genes
Now: 1,800 plus additional ‘microproteins’ detected – too small to find with traditional methods
How They Were Found
- Mass spectrometry: 3.5 billion spectra analyzed
- Immunopeptidomics: Detected proteins displayed on cell surfaces (240M spectra)
- CRISPR screening: Proved some are essential for cell survivals
Why This is Important
- Cancer immunotherapy: These microproteins appear on tumor cells – new treatment targets
- Drug development: Some control cell division and DNA repair
- Genetic disease: May explain conditions with no known causes
New Category: ‘Peptideins’
Proteins we can now detect but don’t fully understand yet – opening new research frontiers”
Title: Expanding the human proteome with microproteins and peptideins
Authors: Eric W. Deutsch, Leron W. Kok, Jonathan M. Mudge, Cristian F. Valls, Irwin Jungreis, Jorge Ruiz-Orera, Zhi Sun, Ulrike Kusebauch, Ivo Fierro-Monti, Jennifer G. Abelin, M. Mar Alba, Julie L. Aspden, Sreejan Bandyopadhyay, Kaushik Banerjee, Pavel V. Baranov, Ariel A. Bazzini, Francis Bourassa, Elspeth A. Bruford, Lorenzo Calviello, Steven A. Carr, Anne-Ruxandra Carvunis, Sonia Chothani, Jim Clauwaert, Kellie Dean, Pouya Faridi, Adam Frankish, Amy Goodale, Thomas Green, Norbert Hubner, Nicholas T. Ingolia, Manolis Kellis, Michele Magrane, Maria Jesus Martin, Thomas F. Martinez, Gerben Menschaert, Uwe Ohler, Sandra Orchard, Alisa Potter, Owen J. L. Rackham, Matthew G. Rees, David E. Root, Jennifer A. Roth, Xavier Roucou, Fernando J. Sialana, Sarah A. Slavoff, Michał I. Świrski, Jack A. S. Tierney, Félix-Antoine Trifiro, Eivind Valen, Valeriia Vasylieva, Aaron Wacholder, Shengbo Wang, Li Wang, Jonathan S. Weissman, Wei Wu, Zhi Xie, Jyoti S. Choudhary, Michal Bassani-Sternberg, Juan Antonio Vizcaíno, Nicola Ternette, Marie A. Brunet, Robert L. Moritz, John R. Prensner and Sebastiaan van Heesch
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