Drug-Induced Immune Haemolytic Anaemia: A Decade Review by Abdul Mannan
Abdul Mannan, Consultant Haematologist at Betsi Cadwaladr University Health Board, shared on LinkedIn:
”Sometimes diagnosing drug-induced immune haemolytic anaemia (DIIHA) feels like chasing a unicorn among zebras.
What looks like a straightforward AIHA can suddenly turn on its head when a culprit drug is revealed.
A decade of pharmacovigilance data from France has now reminded us that the “usual suspects” (antibiotics, anti-inflammatories, etc.) are no longer alone—immune checkpoint inhibitors have officially joined the list.
The lesson is clear:
- Never underestimate the power of a careful drug history.
- A positive DAT is not the end of the story—it’s the start of the detective work.
- Always challenge your diagnostic assumptions before risking re-exposure.
As our therapeutic toolbox expands, so too does the responsibility to spot these rare but serious events.
Grateful for the international haematology community that keeps pushing vigilance forward and protecting patients.”
Read the full paper in BJ Haem.
Article: A decade of pharmacovigilance in France: Immune checkpoints join the list of usual suspects for drug-induced immune haemolytic anaemia
Authors: Guillaume Brenac, Anne Dautriche, Romane Freppel, Anthony Facile, Bruno Revol, Mathilde Beurrier, Bernard Bonnotte, Sylvain Audia
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