Claudio Laudani/X
Nov 18, 2025, 15:08
Claudio Laudani: DOACs Have Transformed the Landscape of Anticoagulation
Claudio Laudani, Cardiovascular Disease Fellow UNICT, Post-Doc Research Scholar UFHealth JAX, shared on LinkedIn:
”Direct oral anticoagulants (DOACs) have transformed the landscape of anticoagulation, offering more predictable pharmacology, improved safety, and easier management compared to vitamin K antagonists.
In this comprehensive review, we examine:
- Pharmacokinetic and pharmacodynamic profiles of apixaban, rivaroxaban, dabigatran, and edoxaban.
- Evidence supporting their use across atrial fibrillation, venous thromboembolism, cancer-associated thrombosis, and atherosclerosis compared with other antithrombotic strategies.
- How to optimize DOAC therapy in vulnerable scenarios (renal impairment, elderly patients, perioperative management).
- Remaining gaps and unmet clinical needs where further research is required, such as patients with rheumatic heart disease, mechanical heart valves, antiphospholipid syndrome, and patients with LVAD.”
Read the full article here.
Article: Safety and optimal use of direct oral anticoagulant therapy
Authors: Claudio Laudani, Luis Ortega-Paz, Ali Zgheib, Georges El Khoury, Mohmmad Alawajneh, Maryam Farahmandsadr, Davide Capodanno, Dominick J Angiolillo
Stay updated on all scientific advances in the field of thrombosis with Hemostasis Today.
-
Oct 4, 2026, 06:12David McIntosh: 900 Plasma Donations One Patient One Lifeline
-
Oct 4, 2026, 06:00Aadil Sheikh: Menopausal Hormone Therapy and Thrombosis Rethinking Route Dose and Risk
-
Oct 4, 2026, 05:39Alicja Urbaniak: Targeting CD148 for Novel Antithrombotic Therapy
-
Oct 4, 2026, 05:27Nirali Thakkar: Influenza and Myocardial Infarction An Unexpected Cardiovascular Connection
-
Oct 4, 2026, 05:03Hisham Fahmi: Thromboprophylaxis in Children With ALL A Risk Adapted Approach
-
Oct 4, 2026, 05:00Mary Cushman: Erin Michos Highlights Rising Heart Disease Mortality Among Younger Women in the US
-
Oct 4, 2026, 04:48Liv Tybjærg Nordestgaard: Is Fasting Necessary Before Blood Sampling?
-
Oct 4, 2026, 04:31Sonal Sonu: Gen Z doesn’t just set trends – Gen Z saves lives
-
Oct 4, 2026, 04:22Registration Opens for 2027 Highlights of ASH – American Society of Hematology