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Can Adipose Tissue Browning Become a New Frontier in Cardiometabolic Prevention?
Ana Checa-Ros/LinkedIn
Nov 22, 2025, 13:59

Can Adipose Tissue Browning Become a New Frontier in Cardiometabolic Prevention?

Atherosclerosis posted on LinkedIn:

”Can adipose tissue browning become a new frontier in cardiometabolic prevention?

Emerging research is uncovering how browning of white adipose tissue (AT) – the conversion to a more metabolically active, thermogenic phenotype – could improve both metabolic and cardiovascular health.

  • Pro-inflammatory pathways (NLRP3, TLR4, NF-κB) inhibit browning
  • Anti-inflammatory signals (IL-4, IL-13, M2 macrophages) promote it, enhancing insulin sensitivity and glucose tolerance
  • Mitochondrial effectors – UCP-1 and PGC1-α – are key drivers of thermogenesis
  • Experimental interventions (ASK-1 knockout, nitrate, melatonin) improved endothelial function, atherosclerosis, and liver steatosis

While evidence is still largely preclinical, these findings suggest that targeting adipose tissue inflammation and mitochondrial function could open new therapeutic avenues for atherosclerotic cardiovascular disease.

Could “browning” therapies become part of the next generation of cardiometabolic treatments?”

Read the full article here.

Title: Molecular mechanisms linking adipose tissue browning to reduced cardiovascular risk

Authors: Ana Checa-Rosa, Luis D’Marco

Cardiometabolic

 

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