How NETs Drive Cardiorenal Damage in Diabetes – Nicolas Schommer and Team
Nicolas Schommer, Postdoctoral Researcher at Boston Children’s Hospital, posted on LinkedIn:
”I’m incredibly grateful and proud to share that our study on how neutrophils, NETs, and PAD4 drive diabetic heart and kidney injury has just been published online in the European Heart Journal.
This publication marks an important milestone in my scientific career and I owe immense gratitude to the people and institutions who made it possible.
Diabetes is known to elevate cardiovascular and renal risk, yet the mechanisms linking neutrophils to multi-organ damage remain unclear. In this study, combining patient biopsies with a longitudinal STZ model, we show that diabetes triggers inflammasome activation and NETosis in neutrophils, promoting inflammation and fibrosis in both the heart and kidneys. Importantly, PAD4 deficiency prevented these neutrophil-driven effects and preserved cardiac and renal function.
My heartfelt thanks go to:
Prof. Denisa D. Wagner (Boston Children’s Hospital / Harvard Medical School) – for outstanding mentorship, guidance, and the opportunity to grow scientifically in such an inspiring environment.
PD. Dr. Lukas Heger (Universitätsklinikum Freiburg) – for exceptional scientific collaboration, and for being a true partner in crime and friend throughout the journey.
Prof. Daniel Duerschmied (Universitätsmedizin Mannheim, Heidelberg University) – for years of support and for shaping my development in cardiovascular medicine and research.
I am also grateful for the collaborative support across
Boston Children’s Hospital, Harvard Medical School, HI-TAC, Universitätsmedizin Mannheim, Heidelberg University, Universitätsklinikum Freiburg, Universitätsklinikum Tübingen
This work represents the collective effort of an outstanding team, and I’m deeply thankful to everyone who contributed to making it a reality.
Onwards – so much more to discover in cardiometabolic inflammation.”
Read the full article here.
Title: Neutrophil extracellular traps and peptidylarginine deiminase 4–mediated inflammasome activation link diabetes to cardiorenal injury and heart failure
Authors: Nicolas Schommer, Nicolas Gendron, Krystin Krauel, Stijn Van Bruggen, Pierre-André Jarrot, Alexander Maier, William Chan, Harald F Langer, Daniel Duerschmied, Dirk Westermann, Karin Klingel, Denisa D Wagner, Lukas A Heger
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