Roberta Gualtierotti: How Do Sex and Gender Influence VTE in Patients with Cancer?
Roberta Gualtierotti, Associate Professor of Internal Medicine at the University of Milan, posted on LinkedIn about a recent article she and her colleagues co-authored, adding:
”Cancer-associated thrombosis (CAT) remains one of the leading causes of morbidity and mortality in oncology.
Yet one important dimension of risk is still insufficiently explored: sex and gender differences.
How do sex and gender influence venous thromboembolism (VTE) in patients with cancer?
Men generally show a higher overall incidence of cancer-associated VTE.
- Women may experience earlier thrombotic events, often related to anticancer therapies.
- Biological differences in coagulation and inflammation may contribute to these patterns, although the underlying mechanisms are still not fully understood.
- Sex-related disparities also appear in treatment complications, including bleeding risk and abnormal uterine bleeding in anticoagulated women of reproductive age.
- In hematologic malignancies, evidence on sex differences in thrombosis remains limited and inconsistent.
In addition, gender-related inequalities in clinical trial participation still affect the interpretation of available data.
Overall, current evidence supports sex as a clinically relevant modifier of cancer-associated thrombosis risk.
Advancing research that systematically integrates sex- and gender-informed analyses and sex-stratified reporting will be essential to improve mechanistic understanding and support precision medicine in thrombosis and oncology.”
Title: Sex Differences in Cancer-Associated Thrombosis
Authors: Andrea Giachi, Davide Santagata, Addolorata Truma, Andrea Artoni, Paolo Bucciarelli, Luca Valenti, Cihan Ay, Roberta Gualtierotti
Read the Full Article on International Journal of Molecular Sciences
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