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Improving Pregnancy Outcomes in Patients with von Willebrand Disease – RPTH
RPTH Journal
Mar 23, 2026, 15:44

Improving Pregnancy Outcomes in Patients with von Willebrand Disease – RPTH

Research and Practice in Thrombosis and Haemostasis (RPTH) shared a post on LinkedIn about a recent article by Ming Y. Lim et al, adding:

“Pregnancy in von Willebrand disease (VWD): Are outcomes improving?

Despite increased awareness and specialized care, this new statewide cohort indicates that risk remains elevated.

Key findings:

Compared to matched controls:

  • 12.8 times higher odds of transfusion
  • High preterm birth (aOR ~1.8)
  • No significant increase in reported PPH (recent cohort)

Important nuance

The lack of PPH signal doesn’t mean “no bleeding risk”:

  • Transfusion rates remain high
  • Suggests bleeding plus anemia (e.g., iron deficiency) may be underappreciated drivers

What this tells us, even in modern care:

  • VWD still impacts maternal outcomes
  • Traditional endpoints (like PPH) may miss part of the picture
  • Pre-delivery optimization (iron, hemostasis) matters as much as delivery management

Clinical direction

  • Multidisciplinary care (Heme plus MFM)
  • Routine iron deficiency screening
  • Better peripartum planning”

Title: Pregnancy outcomes in women with Von Willebrand disease: a statewide cohort study

Authors: Ming Y Lim, G Bryce Christensen, George M. Rodgers, Sara Simonsen

Read the Full Article on RPTH

Rpth

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G Bryce Christensen George M. Rodgers Health Hematology Hemostasis Hemostasis News Hemostasis Today ISTH Medicine Ming Y. Lim Pregnancy Research and Practice in Thrombosis and Haemostasis rpth Sara Simonsen Von Willebrand Disease VWD
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