RPTH Journal
Mar 23, 2026, 15:44
Improving Pregnancy Outcomes in Patients with von Willebrand Disease – RPTH
Research and Practice in Thrombosis and Haemostasis (RPTH) shared a post on LinkedIn about a recent article by Ming Y. Lim et al, adding:
“Pregnancy in von Willebrand disease (VWD): Are outcomes improving?
Despite increased awareness and specialized care, this new statewide cohort indicates that risk remains elevated.
Key findings:
Compared to matched controls:
- 12.8 times higher odds of transfusion
- High preterm birth (aOR ~1.8)
- No significant increase in reported PPH (recent cohort)
Important nuance
The lack of PPH signal doesn’t mean “no bleeding risk”:
- Transfusion rates remain high
- Suggests bleeding plus anemia (e.g., iron deficiency) may be underappreciated drivers
What this tells us, even in modern care:
- VWD still impacts maternal outcomes
- Traditional endpoints (like PPH) may miss part of the picture
- Pre-delivery optimization (iron, hemostasis) matters as much as delivery management
Clinical direction
- Multidisciplinary care (Heme plus MFM)
- Routine iron deficiency screening
- Better peripartum planning”
Title: Pregnancy outcomes in women with Von Willebrand disease: a statewide cohort study
Authors: Ming Y Lim, G Bryce Christensen, George M. Rodgers, Sara Simonsen
Read the Full Article on RPTH
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