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Shehab Mohamed: A Systematic Review on Bleeding as Initial Presentation of CML
Shehab Mohamed/LinkedIn
Apr 28, 2026, 13:13

Shehab Mohamed: A Systematic Review on Bleeding as Initial Presentation of CML

Shehab Mohamed, Hematologist at Hamad Medical Corporation, shared on LinkedIn about a recent article by Mohammad ALTermanini et al, published in Clinical and Applied Thrombosis/Hemostasis, adding:

”Continuing our work in myeloid neoplasms and hemostasis

We are proud to share our latest progress in this evolving field.

After previously exploring:

  • Bleeding in acute myeloid leukemia (AML)
  • Thrombosis in acute promyelocytic leukemia (APL)
  • We now expand our work with a new systematic review on bleeding as the initial presentation of chronic myeloid leukemia (CML).

Key findings from our review:

  • 53 reported cases identified across the literature
  • Strong male predominance (74%)
  • Median age: 45 years

Central nervous system bleeding was the most common presentation (40%), followed by:

  • Soft tissue hematomas (25%)
  • Visceral/splenic bleeding (19%)
  • Most patients presented with marked hyperleukocytosis

Despite severity:

  • 62% survived
  • 21% mortality, mainly due to intracranial hemorrhage or splenic rupture

Key message: Bleeding can be the first manifestation of CML – and should not be overlooked, especially in patients presenting with unexplained hemorrhage and extreme leukocytosis.

This work highlights:

  • The complex interplay between malignancy and hemostasis
  • The need for early recognition
  • The importance of multidisciplinary management

We are excited to keep pushing forward in this field with our team – more to come.”

Title: Review of Bleeding as Initial Presentation in Patients with Chronic Myeloid Leukemia

Authors: Mohammad ALTermanini, Omar Altrmanini, Abdulrhaman F. Al-Mashdali, Ashraf Ahmed, Sara Saeed, Mohamed Fawzi Mudarres, Mohamed Saeed, ElMustafa Abdalla, Dina Soliman, Kalpana Singh, Amin Saied, Motaz Almahmood, Aasir Suliman, Hanaa Qasim, Tareq Abuasab, Fadi Haddad, Mohamed Yassin, Shehab Fareed

Shehab Mohamed: A Systematic Review on Bleeding as Initial Presentation of CML

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Aasir Suliman Abdulrhaman F. Al-Mashdali Amin Saied AML aPL Ashraf Ahmed bleeding CML Dina Soliman ElMustafa Abdalla Fadi Haddad Hanaa Qasim Health Hematology Hemostasis Hemostasis News Hemostasis Today Kalpana Singh Leukemia Medicine Mohamed Fawzi Mudarres Mohamed Saeed Mohamed Yassin Mohammad ALTermanini Motaz Almahmood Omar Altrmanini OncoDaily Sara Saeed Shehab Fareed Tareq Abuasab
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