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Soumen Bhattacharyya: Hyperhomocysteinemia and Thrombosis – What Clinicians Should Know
Soumen Bhattacharyya/LinkedIn
May 5, 2026, 15:28

Soumen Bhattacharyya: Hyperhomocysteinemia and Thrombosis – What Clinicians Should Know

Soumen Bhattacharyya, College Teacher in the Department of Physiology at RBC College for Women, shared a post on LinkedIn:

“Hyperhomocysteinemia and Thrombosis – What Clinicians Should Know

Hyperhomocysteinemia continues to sit in that interesting grey zone between biochemical abnormality and clinical significance.

What’s happening?

Elevated homocysteine levels can:

  • Damage vascular endothelium
  • Increase oxidative stress
  • Promote a pro-thrombotic state

Clinical relevance:

Strongly associated with thrombosis in severe elevations (e.g., genetic disorders)

In mild-to-moderate cases, the evidence is inconsistent and debated

Treatment paradox:

While folate, Vitamin B12, and B6 effectively reduce homocysteine levels…

This doesn’t consistently translate into reduced thrombotic events.

Takeaway for practice:

Hyperhomocysteinemia is best viewed as a modifiable risk marker rather than a standalone cause of thrombosis.

It reminds us of a broader principle in medicine:

Not everything we can measure needs to be aggressively treated in isolation.

Curious to hear from fellow clinicians – Do you routinely screen for homocysteine in thrombotic workups?”

Soumen Bhattacharyya

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